Cell type atlas - APEH - The Human Protein Atlas

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APEH

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	APEH
Gene descriptionⁱ Full gene name according to HGNC.	Acylaminoacyl-peptide hydrolase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	22 NX
Lung	22 NX

B-cells	16 NX
Liver	24 NX
Colon	18 NX
Kidney	13 NX

Basal glandular cells	20 NX
Prostate	20 NX

Basal keratinocytes	8 NX
Skin	8 NX

Bipolar cells	8 NX
Eye	8 NX

Cardiomyocytes	42 NX
Heart muscle	42 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	9 NX
Lung	9 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	73 NX
Placenta	73 NX

Distal tubular cells	37 NX
Kidney	37 NX

Ductal cells	39 NX
Pancreas	39 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	8 NX
Placenta	19 NX
Heart muscle	18 NX
Liver	16 NX
Testis	10 NX
Eye	8 NX
Lung	6 NX
Prostate	4 NX
Pancreas	4 NX
Skin	4 NX

Enterocytes	74 NX
Colon	85 NX
Small intestine	74 NX
Rectum	57 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	30 NX
Pancreas	30 NX

Extravillous trophoblasts	55 NX
Placenta	55 NX

Fibroblasts	13 NX
Placenta	34 NX
Lung	13 NX
Heart muscle	13 NX
Skin	12 NX
Prostate	9 NX

Glandular cells	15 NX
Prostate	15 NX

Granulocytes	23 NX
Colon	28 NX
Lung	19 NX

Hepatocytes	65 NX
Liver	65 NX

Hofbauer cells	46 NX
Placenta	45 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	25 NX
Rectum	31 NX
Colon	20 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	37 NX
Liver	37 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	14 NX
Testis	14 NX

Macrophages	18 NX
Pancreas	40 NX
Kidney	27 NX
Lung	21 NX
Prostate	20 NX
Testis	16 NX
Skin	13 NX

Melanocytes	20 NX
Skin	20 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	45 NX
Colon	50 NX
Rectum	44 NX
Small intestine	36 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	36 NX
Pancreas	36 NX

Paneth cells	29 NX
Rectum	44 NX
Colon	29 NX
Small intestine	25 NX

Peritubular cells	13 NX
Testis	13 NX

Proximal tubular cells	65 NX
Kidney	65 NX

Rod photoreceptor cells	10 NX
Eye	10 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	14 NX
Pancreas	38 NX
Heart muscle	16 NX
Prostate	14 NX
Skin	10 NX

Spermatocytes	31 NX
Testis	31 NX

Spermatogonia	28 NX
Testis	28 NX

Suprabasal keratinocytes	8 NX
Skin	8 NX

Syncytiotrophoblasts	52 NX
Placenta	52 NX

T-cells	25 NX
Kidney	40 NX
Liver	27 NX
Lung	26 NX
Colon	25 NX
Prostate	13 NX
Skin	11 NX

Undifferentiated cells	51 NX
Colon	83 NX
Rectum	54 NX
Small intestine	46 NX

Urothelial cells	21 NX
Prostate	21 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.