Cell type atlas - LRPAP1 - The Human Protein Atlas

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LRPAP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LRPAP1
Gene descriptionⁱ Full gene name according to HGNC.	LDL receptor related protein associated protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	101 NX
Lung	101 NX

Alveolar cells type 2	72 NX
Lung	72 NX

B-cells	70 NX
Liver	120 NX
Colon	70 NX
Kidney	58 NX

Basal glandular cells	148 NX
Prostate	148 NX

Basal keratinocytes	60 NX
Skin	60 NX

Bipolar cells	65 NX
Eye	65 NX

Cardiomyocytes	138 NX
Heart muscle	138 NX

Cholangiocytes	94 NX
Liver	94 NX

Ciliated cells	111 NX
Lung	111 NX

Club cells	83 NX
Lung	83 NX

Collecting duct cells	185 NX
Kidney	185 NX

Cone photoreceptor cells	43 NX
Eye	43 NX

Cytotrophoblasts	501 NX
Placenta	501 NX

Distal tubular cells	43 NX
Kidney	43 NX

Ductal cells	138 NX
Pancreas	138 NX

Early spermatids	30 NX
Testis	30 NX

Endothelial cells	85 NX
Eye	139 NX
Pancreas	115 NX
Lung	96 NX
Placenta	91 NX
Skin	89 NX
Prostate	85 NX
Testis	72 NX
Heart muscle	71 NX
Liver	61 NX

Enterocytes	141 NX
Colon	165 NX
Small intestine	161 NX
Rectum	95 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	94 NX
Pancreas	94 NX

Extravillous trophoblasts	145 NX
Placenta	145 NX

Fibroblasts	164 NX
Prostate	196 NX
Heart muscle	169 NX
Placenta	167 NX
Skin	116 NX
Lung	76 NX

Glandular cells	116 NX
Prostate	116 NX

Granulocytes	80 NX
Colon	92 NX
Lung	67 NX

Hepatocytes	88 NX
Liver	88 NX

Hofbauer cells	226 NX
Placenta	226 NX

Horizontal cells	37 NX
Eye	37 NX

Intestinal endocrine cells	79 NX
Colon	88 NX
Rectum	70 NX

Ito cells	48 NX
Liver	48 NX

Kupffer cells	92 NX
Liver	92 NX

Late spermatids	43 NX
Testis	43 NX

Leydig cells	117 NX
Testis	117 NX

Macrophages	130 NX
Pancreas	503 NX
Lung	217 NX
Prostate	153 NX
Kidney	151 NX
Testis	108 NX
Skin	77 NX

Melanocytes	140 NX
Skin	140 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	128 NX
Pancreas	128 NX

Mucus-secreting cells	72 NX
Colon	178 NX
Small intestine	76 NX
Rectum	59 NX

Muller glia cells	127 NX
Eye	127 NX

Pancreatic endocrine cells	92 NX
Pancreas	92 NX

Paneth cells	102 NX
Colon	216 NX
Small intestine	102 NX
Rectum	95 NX

Peritubular cells	143 NX
Testis	143 NX

Proximal tubular cells	236 NX
Kidney	236 NX

Rod photoreceptor cells	71 NX
Eye	71 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	128 NX
Pancreas	142 NX
Prostate	131 NX
Heart muscle	128 NX
Skin	87 NX

Spermatocytes	198 NX
Testis	198 NX

Spermatogonia	167 NX
Testis	167 NX

Suprabasal keratinocytes	54 NX
Skin	54 NX

Syncytiotrophoblasts	580 NX
Placenta	580 NX

T-cells	69 NX
Kidney	111 NX
Skin	98 NX
Colon	92 NX
Lung	91 NX
Liver	67 NX
Prostate	65 NX

Undifferentiated cells	81 NX
Colon	126 NX
Rectum	81 NX
Small intestine	66 NX

Urothelial cells	128 NX
Prostate	128 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.