Cell type atlas - GNL3 - The Human Protein Atlas

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GNL3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNL3
Gene descriptionⁱ Full gene name according to HGNC.	G protein nucleolar 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	42 NX
Lung	42 NX

B-cells	76 NX
Liver	100 NX
Colon	85 NX
Kidney	67 NX

Basal glandular cells	90 NX
Prostate	90 NX

Basal keratinocytes	145 NX
Skin	145 NX

Bipolar cells	18 NX
Eye	18 NX

Cardiomyocytes	47 NX
Heart muscle	47 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	59 NX
Lung	59 NX

Club cells	134 NX
Lung	134 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	65 NX
Placenta	65 NX

Distal tubular cells	35 NX
Kidney	35 NX

Ductal cells	72 NX
Pancreas	72 NX

Early spermatids	42 NX
Testis	42 NX

Endothelial cells	46 NX
Prostate	92 NX
Pancreas	79 NX
Skin	64 NX
Lung	64 NX
Liver	49 NX
Heart muscle	44 NX
Testis	41 NX
Placenta	34 NX
Eye	27 NX

Enterocytes	17 NX
Colon	21 NX
Small intestine	17 NX
Rectum	13 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	90 NX
Pancreas	90 NX

Extravillous trophoblasts	95 NX
Placenta	95 NX

Fibroblasts	61 NX
Prostate	288 NX
Lung	154 NX
Heart muscle	100 NX
Skin	58 NX
Placenta	56 NX

Glandular cells	75 NX
Prostate	75 NX

Granulocytes	59 NX
Lung	100 NX
Colon	18 NX

Hepatocytes	40 NX
Liver	40 NX

Hofbauer cells	36 NX
Placenta	36 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	46 NX
Colon	61 NX
Rectum	31 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	21 NX
Liver	21 NX

Late spermatids	20 NX
Testis	20 NX

Leydig cells	48 NX
Testis	48 NX

Macrophages	43 NX
Skin	64 NX
Lung	64 NX
Testis	38 NX
Prostate	37 NX
Pancreas	33 NX
Kidney	26 NX

Melanocytes	74 NX
Skin	74 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	75 NX
Pancreas	75 NX

Mucus-secreting cells	52 NX
Colon	103 NX
Rectum	57 NX
Small intestine	28 NX

Muller glia cells	17 NX
Eye	17 NX

Pancreatic endocrine cells	85 NX
Pancreas	85 NX

Paneth cells	25 NX
Rectum	58 NX
Small intestine	25 NX
Colon	12 NX

Peritubular cells	32 NX
Testis	32 NX

Proximal tubular cells	31 NX
Kidney	31 NX

Rod photoreceptor cells	12 NX
Eye	12 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	95 NX
Prostate	134 NX
Skin	128 NX
Pancreas	95 NX
Heart muscle	36 NX

Spermatocytes	33 NX
Testis	33 NX

Spermatogonia	59 NX
Testis	59 NX

Suprabasal keratinocytes	134 NX
Skin	134 NX

Syncytiotrophoblasts	76 NX
Placenta	76 NX

T-cells	46 NX
Colon	90 NX
Lung	85 NX
Skin	72 NX
Prostate	70 NX
Kidney	46 NX
Liver	26 NX

Undifferentiated cells	64 NX
Colon	93 NX
Small intestine	64 NX
Rectum	57 NX

Urothelial cells	113 NX
Prostate	113 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.