Cell type atlas - TIPARP - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TIPARP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TIPARP
Gene descriptionⁱ Full gene name according to HGNC.	TCDD inducible poly(ADP-ribose) polymerase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Urothelial cells, Basal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HBEC3-KT)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Urothelial cells, Basal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	80 NX
Lung	80 NX

Alveolar cells type 2	77 NX
Lung	77 NX

B-cells	6 NX
Colon	48 NX
Kidney	5 NX
Liver	4 NX

Basal glandular cells	85 NX
Prostate	85 NX

Basal keratinocytes	174 NX
Skin	174 NX

Bipolar cells	4 NX
Eye	4 NX

Cardiomyocytes	21 NX
Heart muscle	21 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	82 NX
Lung	82 NX

Collecting duct cells	7 NX
Kidney	7 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	3 NX
Placenta	3 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	29 NX
Pancreas	29 NX

Early spermatids	204 NX
Testis	204 NX

Endothelial cells	26 NX
Prostate	115 NX
Eye	61 NX
Skin	60 NX
Lung	35 NX
Liver	25 NX
Heart muscle	18 NX
Pancreas	14 NX
Testis	11 NX
Placenta	4 NX

Enterocytes	33 NX
Colon	34 NX
Small intestine	33 NX
Rectum	26 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	7 NX
Placenta	7 NX

Fibroblasts	35 NX
Prostate	187 NX
Skin	75 NX
Lung	70 NX
Heart muscle	35 NX
Placenta	12 NX

Glandular cells	73 NX
Prostate	73 NX

Granulocytes	116 NX
Colon	193 NX
Lung	40 NX

Hepatocytes	17 NX
Liver	17 NX

Hofbauer cells	17 NX
Placenta	17 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	52 NX
Colon	58 NX
Rectum	47 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	16 NX
Liver	16 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	36 NX
Skin	73 NX
Prostate	53 NX
Lung	36 NX
Testis	19 NX
Pancreas	16 NX
Kidney	12 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	21 NX
Pancreas	21 NX

Mucus-secreting cells	22 NX
Colon	44 NX
Small intestine	24 NX
Rectum	18 NX

Muller glia cells	8 NX
Eye	8 NX

Pancreatic endocrine cells	28 NX
Pancreas	28 NX

Paneth cells	28 NX
Colon	60 NX
Small intestine	28 NX
Rectum	19 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	8 NX
Kidney	8 NX

Rod photoreceptor cells	9 NX
Eye	9 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	58 NX
Prostate	147 NX
Skin	108 NX
Heart muscle	15 NX
Pancreas	7 NX

Spermatocytes	62 NX
Testis	62 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	106 NX
Skin	106 NX

Syncytiotrophoblasts	6 NX
Placenta	6 NX

T-cells	35 NX
Skin	153 NX
Colon	146 NX
Prostate	74 NX
Lung	35 NX
Liver	21 NX
Kidney	12 NX

Undifferentiated cells	12 NX
Colon	26 NX
Rectum	12 NX
Small intestine	11 NX

Urothelial cells	187 NX
Prostate	187 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.