Cell type atlas - PPM1K - The Human Protein Atlas

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PPM1K

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPM1K
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase, Mg2+/Mn2+ dependent 1K
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Daudi, Karpas-707, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	11 NX
Lung	11 NX

B-cells	104 NX
Colon	128 NX
Liver	102 NX
Kidney	80 NX

Basal glandular cells	17 NX
Prostate	17 NX

Basal keratinocytes	9 NX
Skin	9 NX

Bipolar cells	97 NX
Eye	97 NX

Cardiomyocytes	417 NX
Heart muscle	417 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	17 NX
Lung	17 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	9 NX
Placenta	9 NX

Distal tubular cells	133 NX
Kidney	133 NX

Ductal cells	6 NX
Pancreas	6 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	18 NX
Heart muscle	80 NX
Eye	41 NX
Prostate	32 NX
Skin	24 NX
Testis	15 NX
Lung	15 NX
Placenta	12 NX
Liver	9 NX
Pancreas	7 NX

Enterocytes	2 NX
Small intestine	6 NX
Colon	1 NX
Rectum	0 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	5 NX
Pancreas	5 NX

Extravillous trophoblasts	3 NX
Placenta	3 NX

Fibroblasts	28 NX
Heart muscle	113 NX
Prostate	49 NX
Lung	41 NX
Placenta	28 NX
Skin	25 NX

Glandular cells	31 NX
Prostate	31 NX

Granulocytes	19 NX
Lung	19 NX
Colon	18 NX

Hepatocytes	22 NX
Liver	22 NX

Hofbauer cells	23 NX
Placenta	23 NX

Horizontal cells	81 NX
Eye	81 NX

Intestinal endocrine cells	9 NX
Rectum	12 NX
Colon	7 NX

Ito cells	20 NX
Liver	20 NX

Kupffer cells	11 NX
Liver	11 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	22 NX
Testis	22 NX

Macrophages	14 NX
Testis	27 NX
Prostate	24 NX
Lung	19 NX
Skin	12 NX
Kidney	12 NX
Pancreas	12 NX

Melanocytes	20 NX
Skin	20 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	111 NX
Pancreas	111 NX

Mucus-secreting cells	16 NX
Colon	19 NX
Rectum	15 NX
Small intestine	12 NX

Muller glia cells	19 NX
Eye	19 NX

Pancreatic endocrine cells	6 NX
Pancreas	6 NX

Paneth cells	5 NX
Small intestine	18 NX
Rectum	5 NX
Colon	3 NX

Peritubular cells	30 NX
Testis	30 NX

Proximal tubular cells	39 NX
Kidney	39 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	39 NX
Heart muscle	57 NX
Prostate	41 NX
Skin	36 NX
Pancreas	11 NX

Spermatocytes	36 NX
Testis	36 NX

Spermatogonia	21 NX
Testis	21 NX

Suprabasal keratinocytes	5 NX
Skin	5 NX

Syncytiotrophoblasts	2 NX
Placenta	2 NX

T-cells	55 NX
Colon	58 NX
Prostate	57 NX
Liver	55 NX
Kidney	55 NX
Skin	50 NX
Lung	49 NX

Undifferentiated cells	3 NX
Small intestine	5 NX
Rectum	2 NX
Colon	2 NX

Urothelial cells	6 NX
Prostate	6 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.