Cell type atlas - RPL22L1 - The Human Protein Atlas

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RPL22L1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPL22L1
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal protein L22 like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	37 NX
Lung	37 NX

B-cells	275 NX
Liver	640 NX
Colon	312 NX
Kidney	178 NX

Basal glandular cells	202 NX
Prostate	202 NX

Basal keratinocytes	176 NX
Skin	176 NX

Bipolar cells	13 NX
Eye	13 NX

Cardiomyocytes	15 NX
Heart muscle	15 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	92 NX
Lung	92 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	84 NX
Placenta	84 NX

Distal tubular cells	56 NX
Kidney	56 NX

Ductal cells	133 NX
Pancreas	133 NX

Early spermatids	31 NX
Testis	31 NX

Endothelial cells	90 NX
Prostate	350 NX
Testis	226 NX
Placenta	115 NX
Eye	110 NX
Skin	94 NX
Pancreas	90 NX
Liver	67 NX
Lung	53 NX
Heart muscle	15 NX

Enterocytes	76 NX
Small intestine	86 NX
Colon	75 NX
Rectum	49 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	200 NX
Pancreas	200 NX

Extravillous trophoblasts	252 NX
Placenta	252 NX

Fibroblasts	105 NX
Prostate	292 NX
Placenta	182 NX
Lung	146 NX
Skin	91 NX
Heart muscle	26 NX

Glandular cells	162 NX
Prostate	162 NX

Granulocytes	105 NX
Colon	129 NX
Lung	81 NX

Hepatocytes	91 NX
Liver	91 NX

Hofbauer cells	170 NX
Placenta	170 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	139 NX
Colon	170 NX
Rectum	108 NX

Ito cells	88 NX
Liver	88 NX

Kupffer cells	141 NX
Liver	141 NX

Late spermatids	29 NX
Testis	29 NX

Leydig cells	129 NX
Testis	129 NX

Macrophages	90 NX
Prostate	271 NX
Testis	191 NX
Kidney	125 NX
Skin	89 NX
Lung	68 NX
Pancreas	66 NX

Melanocytes	74 NX
Skin	74 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	58 NX
Pancreas	58 NX

Mucus-secreting cells	131 NX
Colon	345 NX
Rectum	134 NX
Small intestine	112 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	350 NX
Pancreas	350 NX

Paneth cells	115 NX
Rectum	151 NX
Colon	115 NX
Small intestine	105 NX

Peritubular cells	84 NX
Testis	84 NX

Proximal tubular cells	69 NX
Kidney	69 NX

Rod photoreceptor cells	18 NX
Eye	18 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	95 NX
Pancreas	414 NX
Prostate	264 NX
Skin	85 NX
Heart muscle	9 NX

Spermatocytes	48 NX
Testis	48 NX

Spermatogonia	26 NX
Testis	26 NX

Suprabasal keratinocytes	217 NX
Skin	217 NX

Syncytiotrophoblasts	82 NX
Placenta	82 NX

T-cells	127 NX
Prostate	288 NX
Colon	196 NX
Skin	140 NX
Liver	125 NX
Kidney	86 NX
Lung	83 NX

Undifferentiated cells	151 NX
Colon	330 NX
Small intestine	134 NX
Rectum	103 NX

Urothelial cells	275 NX
Prostate	275 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.