Cell type atlas - ELF3 - The Human Protein Atlas

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ELF3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ELF3
Gene descriptionⁱ Full gene name according to HGNC.	E74 like ETS transcription factor 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Enterocytes, Paneth cells, Glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, CAPAN-2, OE19, RT4, SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Enterocytes, Paneth cells, Glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	274 NX
Lung	274 NX

Alveolar cells type 2	377 NX
Lung	377 NX

B-cells	5 NX
Colon	76 NX
Kidney	9 NX
Liver	1 NX

Basal glandular cells	575 NX
Prostate	575 NX

Basal keratinocytes	5 NX
Skin	5 NX

Bipolar cells	2 NX
Eye	2 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	448 NX
Liver	448 NX

Ciliated cells	586 NX
Lung	586 NX

Club cells	344 NX
Lung	344 NX

Collecting duct cells	312 NX
Kidney	312 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	61 NX
Placenta	61 NX

Distal tubular cells	35 NX
Kidney	35 NX

Ductal cells	554 NX
Pancreas	553 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	1 NX
Prostate	59 NX
Lung	26 NX
Pancreas	7 NX
Placenta	3 NX
Eye	2 NX
Skin	1 NX
Heart muscle	1 NX
Testis	0 NX
Liver	0 NX

Enterocytes	1512 NX
Colon	1659 NX
Small intestine	1427 NX
Rectum	1196 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	566 NX
Pancreas	566 NX

Extravillous trophoblasts	108 NX
Placenta	108 NX

Fibroblasts	4 NX
Prostate	63 NX
Lung	52 NX
Placenta	8 NX
Skin	1 NX
Heart muscle	0 NX

Glandular cells	1016 NX
Prostate	1016 NX

Granulocytes	40 NX
Colon	55 NX
Lung	26 NX

Hepatocytes	30 NX
Liver	30 NX

Hofbauer cells	8 NX
Placenta	8 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	434 NX
Rectum	461 NX
Colon	408 NX

Ito cells	1 NX
Liver	1 NX

Kupffer cells	1 NX
Liver	1 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	0 NX
Testis	0 NX

Macrophages	12 NX
Prostate	68 NX
Lung	28 NX
Kidney	17 NX
Pancreas	12 NX
Skin	1 NX
Testis	0 NX

Melanocytes	9 NX
Skin	9 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	25 NX
Pancreas	25 NX

Mucus-secreting cells	963 NX
Colon	1406 NX
Small intestine	1137 NX
Rectum	854 NX

Muller glia cells	2 NX
Eye	2 NX

Pancreatic endocrine cells	453 NX
Pancreas	453 NX

Paneth cells	1044 NX
Colon	2105 NX
Rectum	1044 NX
Small intestine	894 NX

Peritubular cells	0 NX
Testis	0 NX

Proximal tubular cells	114 NX
Kidney	114 NX

Rod photoreceptor cells	64 NX
Eye	64 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	0 NX
Prostate	70 NX
Pancreas	26 NX
Heart muscle	0 NX
Skin	0 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	0 NX
Testis	0 NX

Suprabasal keratinocytes	7 NX
Skin	7 NX

Syncytiotrophoblasts	215 NX
Placenta	215 NX

T-cells	2 NX
Colon	67 NX
Prostate	44 NX
Lung	27 NX
Kidney	20 NX
Skin	2 NX
Liver	0 NX

Undifferentiated cells	774 NX
Colon	1122 NX
Rectum	774 NX
Small intestine	729 NX

Urothelial cells	1630 NX
Prostate	1630 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.