Cell type atlas - S100A9 - The Human Protein Atlas

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S100A9

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	S100A9
Gene descriptionⁱ Full gene name according to HGNC.	S100 calcium binding protein A9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Kupffer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enriched (SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Kupffer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	214 NX
Lung	214 NX

Alveolar cells type 2	574 NX
Lung	574 NX

B-cells	57 NX
Liver	71 NX
Colon	58 NX
Kidney	5 NX

Basal glandular cells	53 NX
Prostate	53 NX

Basal keratinocytes	18 NX
Skin	18 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	3 NX
Heart muscle	3 NX

Cholangiocytes	66 NX
Liver	66 NX

Ciliated cells	112 NX
Lung	112 NX

Club cells	185 NX
Lung	185 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	111 NX
Placenta	111 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	49 NX
Pancreas	49 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	7 NX
Lung	137 NX
Placenta	53 NX
Eye	34 NX
Liver	9 NX
Prostate	7 NX
Heart muscle	5 NX
Skin	2 NX
Testis	1 NX
Pancreas	0 NX

Enterocytes	1 NX
Colon	2 NX
Rectum	0 NX
Small intestine	0 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	33 NX
Pancreas	33 NX

Extravillous trophoblasts	44 NX
Placenta	44 NX

Fibroblasts	7 NX
Lung	420 NX
Placenta	55 NX
Prostate	7 NX
Heart muscle	7 NX
Skin	1 NX

Glandular cells	20 NX
Prostate	20 NX

Granulocytes	151 NX
Lung	302 NX
Colon	0 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	1628 NX
Placenta	1628 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	0 NX
Rectum	0 NX
Colon	0 NX

Ito cells	71 NX
Liver	71 NX

Kupffer cells	11072 NX
Liver	11072 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	6 NX
Testis	6 NX

Macrophages	1163 NX
Kidney	7929 NX
Pancreas	4195 NX
Lung	3128 NX
Testis	1398 NX
Prostate	904 NX
Skin	13 NX

Melanocytes	0 NX
Skin	0 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	2 NX
Colon	6 NX
Rectum	2 NX
Small intestine	2 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	10 NX
Pancreas	10 NX

Paneth cells	1 NX
Colon	3 NX
Rectum	1 NX
Small intestine	0 NX

Peritubular cells	0 NX
Testis	0 NX

Proximal tubular cells	16 NX
Kidney	16 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	3 NX
Prostate	14 NX
Heart muscle	13 NX
Pancreas	3 NX
Skin	1 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	29 NX
Skin	29 NX

Syncytiotrophoblasts	1034 NX
Placenta	1034 NX

T-cells	25 NX
Lung	410 NX
Liver	39 NX
Kidney	26 NX
Prostate	9 NX
Colon	1 NX
Skin	1 NX

Undifferentiated cells	2 NX
Colon	3 NX
Rectum	2 NX
Small intestine	2 NX

Urothelial cells	292 NX
Prostate	292 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.