Cell type atlas - BOLA3 - The Human Protein Atlas

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BOLA3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BOLA3
Gene descriptionⁱ Full gene name according to HGNC.	BolA family member 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells, Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells, Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	28 NX
Lung	28 NX

B-cells	16 NX
Liver	86 NX
Colon	19 NX
Kidney	13 NX

Basal glandular cells	39 NX
Prostate	39 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	28 NX
Eye	28 NX

Cardiomyocytes	268 NX
Heart muscle	268 NX

Cholangiocytes	56 NX
Liver	56 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	31 NX
Lung	31 NX

Collecting duct cells	80 NX
Kidney	80 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	51 NX
Placenta	51 NX

Distal tubular cells	298 NX
Kidney	298 NX

Ductal cells	84 NX
Pancreas	84 NX

Early spermatids	13 NX
Testis	13 NX

Endothelial cells	35 NX
Pancreas	86 NX
Heart muscle	64 NX
Placenta	54 NX
Testis	35 NX
Skin	32 NX
Lung	29 NX
Liver	25 NX
Prostate	21 NX
Eye	20 NX

Enterocytes	79 NX
Colon	147 NX
Rectum	90 NX
Small intestine	70 NX

Erythroid cells	187 NX
Liver	187 NX

Exocrine glandular cells	96 NX
Pancreas	96 NX

Extravillous trophoblasts	140 NX
Placenta	140 NX

Fibroblasts	38 NX
Heart muscle	119 NX
Placenta	60 NX
Skin	35 NX
Lung	22 NX
Prostate	10 NX

Glandular cells	52 NX
Prostate	52 NX

Granulocytes	25 NX
Colon	37 NX
Lung	14 NX

Hepatocytes	87 NX
Liver	87 NX

Hofbauer cells	98 NX
Placenta	98 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	73 NX
Rectum	75 NX
Colon	71 NX

Ito cells	36 NX
Liver	36 NX

Kupffer cells	32 NX
Liver	32 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	31 NX
Testis	31 NX

Macrophages	29 NX
Pancreas	80 NX
Kidney	56 NX
Prostate	34 NX
Testis	29 NX
Skin	24 NX
Lung	20 NX

Melanocytes	95 NX
Skin	95 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	91 NX
Pancreas	91 NX

Mucus-secreting cells	108 NX
Colon	152 NX
Rectum	110 NX
Small intestine	71 NX

Muller glia cells	30 NX
Eye	30 NX

Pancreatic endocrine cells	83 NX
Pancreas	83 NX

Paneth cells	52 NX
Rectum	98 NX
Colon	52 NX
Small intestine	42 NX

Peritubular cells	44 NX
Testis	44 NX

Proximal tubular cells	166 NX
Kidney	166 NX

Rod photoreceptor cells	38 NX
Eye	38 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	44 NX
Pancreas	119 NX
Heart muscle	102 NX
Skin	41 NX
Prostate	21 NX

Spermatocytes	64 NX
Testis	64 NX

Spermatogonia	97 NX
Testis	97 NX

Suprabasal keratinocytes	15 NX
Skin	15 NX

Syncytiotrophoblasts	19 NX
Placenta	19 NX

T-cells	30 NX
Kidney	63 NX
Skin	47 NX
Colon	41 NX
Lung	32 NX
Liver	29 NX
Prostate	13 NX

Undifferentiated cells	161 NX
Colon	213 NX
Rectum	172 NX
Small intestine	109 NX

Urothelial cells	37 NX
Prostate	37 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.