Cell type atlas - ATF3 - The Human Protein Atlas

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ATF3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATF3
Gene descriptionⁱ Full gene name according to HGNC.	Activating transcription factor 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Intestinal endocrine cells, Glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, basophil, intermediate monocyte, myeloid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BEWO, SuSa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Intestinal endocrine cells, Glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	393 NX
Lung	393 NX

Alveolar cells type 2	144 NX
Lung	144 NX

B-cells	8 NX
Colon	79 NX
Liver	8 NX
Kidney	0 NX

Basal glandular cells	235 NX
Prostate	235 NX

Basal keratinocytes	180 NX
Skin	180 NX

Bipolar cells	4 NX
Eye	4 NX

Cardiomyocytes	605 NX
Heart muscle	605 NX

Cholangiocytes	74 NX
Liver	74 NX

Ciliated cells	129 NX
Lung	129 NX

Club cells	135 NX
Lung	135 NX

Collecting duct cells	52 NX
Kidney	52 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	137 NX
Placenta	137 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	158 NX
Pancreas	158 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	136 NX
Eye	359 NX
Prostate	242 NX
Skin	222 NX
Heart muscle	220 NX
Lung	117 NX
Testis	62 NX
Liver	56 NX
Placenta	52 NX
Pancreas	0 NX

Enterocytes	501 NX
Colon	617 NX
Rectum	360 NX
Small intestine	358 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	108 NX
Pancreas	108 NX

Extravillous trophoblasts	257 NX
Placenta	257 NX

Fibroblasts	236 NX
Prostate	585 NX
Lung	341 NX
Heart muscle	283 NX
Skin	248 NX
Placenta	101 NX

Glandular cells	644 NX
Prostate	644 NX

Granulocytes	77 NX
Colon	92 NX
Lung	63 NX

Hepatocytes	21 NX
Liver	21 NX

Hofbauer cells	100 NX
Placenta	100 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	855 NX
Rectum	1014 NX
Colon	697 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	13 NX
Liver	13 NX

Late spermatids	3 NX
Testis	2 NX

Leydig cells	16 NX
Testis	16 NX

Macrophages	212 NX
Prostate	472 NX
Testis	308 NX
Skin	284 NX
Lung	116 NX
Kidney	40 NX
Pancreas	21 NX

Melanocytes	165 NX
Skin	165 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	55 NX
Pancreas	55 NX

Mucus-secreting cells	427 NX
Colon	1156 NX
Rectum	429 NX
Small intestine	415 NX

Muller glia cells	12 NX
Eye	12 NX

Pancreatic endocrine cells	156 NX
Pancreas	156 NX

Paneth cells	312 NX
Colon	751 NX
Small intestine	312 NX
Rectum	236 NX

Peritubular cells	1 NX
Testis	1 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	3 NX
Eye	3 NX

Sertoli cells	97 NX
Testis	97 NX

Smooth muscle cells	421 NX
Prostate	1017 NX
Skin	492 NX
Heart muscle	421 NX
Pancreas	17 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	177 NX
Skin	177 NX

Syncytiotrophoblasts	352 NX
Placenta	352 NX

T-cells	7 NX
Prostate	262 NX
Colon	84 NX
Lung	68 NX
Skin	67 NX
Liver	2 NX
Kidney	1 NX

Undifferentiated cells	216 NX
Colon	370 NX
Small intestine	179 NX
Rectum	177 NX

Urothelial cells	169 NX
Prostate	169 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.