Cell type atlas - DHRS3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DHRS3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DHRS3
Gene descriptionⁱ Full gene name according to HGNC.	Dehydrogenase/reductase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (gdT-cell, naive CD4 T-cell, MAIT T-cell, naive CD8 T-cell, memory CD4 T-cell, memory CD8 T-cell, NK-cell, myeloid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, CAPAN-2, hTERT-RPE1, SK-BR-3, WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	89 NX
Lung	89 NX

Alveolar cells type 2	49 NX
Lung	49 NX

B-cells	4 NX
Liver	5 NX
Kidney	5 NX
Colon	3 NX

Basal glandular cells	142 NX
Prostate	142 NX

Basal keratinocytes	23 NX
Skin	23 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	32 NX
Heart muscle	32 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	59 NX
Lung	59 NX

Club cells	56 NX
Lung	56 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	20 NX
Kidney	20 NX

Ductal cells	82 NX
Pancreas	82 NX

Early spermatids	86 NX
Testis	86 NX

Endothelial cells	37 NX
Liver	209 NX
Pancreas	111 NX
Heart muscle	42 NX
Eye	38 NX
Testis	37 NX
Prostate	30 NX
Placenta	19 NX
Lung	12 NX
Skin	10 NX

Enterocytes	71 NX
Small intestine	88 NX
Rectum	82 NX
Colon	59 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	142 NX
Pancreas	142 NX

Extravillous trophoblasts	39 NX
Placenta	39 NX

Fibroblasts	27 NX
Prostate	53 NX
Heart muscle	42 NX
Lung	27 NX
Placenta	21 NX
Skin	15 NX

Glandular cells	66 NX
Prostate	66 NX

Granulocytes	15 NX
Lung	21 NX
Colon	9 NX

Hepatocytes	158 NX
Liver	158 NX

Hofbauer cells	60 NX
Placenta	60 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	24 NX
Colon	27 NX
Rectum	21 NX

Ito cells	62 NX
Liver	62 NX

Kupffer cells	40 NX
Liver	40 NX

Late spermatids	236 NX
Testis	236 NX

Leydig cells	21 NX
Testis	21 NX

Macrophages	19 NX
Pancreas	176 NX
Prostate	57 NX
Lung	28 NX
Kidney	22 NX
Testis	14 NX
Skin	5 NX

Melanocytes	7 NX
Skin	7 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	17 NX
Pancreas	17 NX

Mucus-secreting cells	31 NX
Small intestine	34 NX
Rectum	30 NX
Colon	23 NX

Muller glia cells	14 NX
Eye	14 NX

Pancreatic endocrine cells	112 NX
Pancreas	112 NX

Paneth cells	49 NX
Colon	89 NX
Rectum	49 NX
Small intestine	49 NX

Peritubular cells	9 NX
Testis	9 NX

Proximal tubular cells	39 NX
Kidney	39 NX

Rod photoreceptor cells	2 NX
Eye	2 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	30 NX
Prostate	50 NX
Skin	33 NX
Heart muscle	29 NX
Pancreas	19 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	22 NX
Placenta	22 NX

T-cells	22 NX
Liver	67 NX
Lung	22 NX
Colon	22 NX
Kidney	15 NX
Skin	15 NX
Prostate	13 NX

Undifferentiated cells	30 NX
Small intestine	33 NX
Rectum	31 NX
Colon	25 NX

Urothelial cells	125 NX
Prostate	125 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.