Cell type atlas - CYB561A3 - The Human Protein Atlas

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CYB561A3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CYB561A3
Gene descriptionⁱ Full gene name according to HGNC.	Cytochrome b561 family member A3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Melanocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (plasmacytoid DC, naive B-cell, memory B-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Melanocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	28 NX
Lung	28 NX

B-cells	119 NX
Kidney	143 NX
Colon	112 NX
Liver	70 NX

Basal glandular cells	16 NX
Prostate	16 NX

Basal keratinocytes	25 NX
Skin	25 NX

Bipolar cells	15 NX
Eye	15 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	29 NX
Lung	29 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	44 NX
Placenta	43 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	23 NX
Pancreas	23 NX

Early spermatids	56 NX
Testis	56 NX

Endothelial cells	12 NX
Lung	26 NX
Eye	17 NX
Testis	16 NX
Skin	15 NX
Placenta	13 NX
Liver	9 NX
Prostate	7 NX
Heart muscle	2 NX
Pancreas	0 NX

Enterocytes	47 NX
Colon	47 NX
Rectum	45 NX
Small intestine	44 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	34 NX
Pancreas	34 NX

Extravillous trophoblasts	35 NX
Placenta	35 NX

Fibroblasts	18 NX
Placenta	19 NX
Skin	18 NX
Lung	18 NX
Prostate	10 NX
Heart muscle	1 NX

Glandular cells	17 NX
Prostate	17 NX

Granulocytes	8 NX
Lung	16 NX
Colon	0 NX

Hepatocytes	19 NX
Liver	19 NX

Hofbauer cells	49 NX
Placenta	49 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	19 NX
Rectum	23 NX
Colon	14 NX

Ito cells	12 NX
Liver	12 NX

Kupffer cells	20 NX
Liver	20 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	19 NX
Testis	19 NX

Macrophages	30 NX
Pancreas	274 NX
Prostate	33 NX
Kidney	29 NX
Lung	28 NX
Skin	24 NX
Testis	18 NX

Melanocytes	304 NX
Skin	304 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	78 NX
Pancreas	78 NX

Mucus-secreting cells	27 NX
Small intestine	29 NX
Colon	26 NX
Rectum	22 NX

Muller glia cells	17 NX
Eye	17 NX

Pancreatic endocrine cells	22 NX
Pancreas	22 NX

Paneth cells	39 NX
Colon	58 NX
Small intestine	39 NX
Rectum	36 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	13 NX
Kidney	13 NX

Rod photoreceptor cells	52 NX
Eye	52 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	12 NX
Pancreas	37 NX
Prostate	13 NX
Skin	11 NX
Heart muscle	2 NX

Spermatocytes	5 NX
Testis	5 NX

Spermatogonia	11 NX
Testis	11 NX

Suprabasal keratinocytes	21 NX
Skin	21 NX

Syncytiotrophoblasts	33 NX
Placenta	33 NX

T-cells	22 NX
Liver	27 NX
Lung	26 NX
Prostate	22 NX
Colon	22 NX
Kidney	19 NX
Skin	15 NX

Undifferentiated cells	27 NX
Colon	30 NX
Small intestine	28 NX
Rectum	23 NX

Urothelial cells	13 NX
Prostate	13 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.