Cell type atlas - DMKN - The Human Protein Atlas

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DMKN

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DMKN
Gene descriptionⁱ Full gene name according to HGNC.	Dermokine
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	27

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Suprabasal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (NK-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A-431, CACO-2, CAPAN-2, HBEC3-KT, RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Suprabasal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	98 NX
Lung	98 NX

Alveolar cells type 2	94 NX
Lung	94 NX

B-cells	4 NX
Colon	6 NX
Kidney	5 NX
Liver	1 NX

Basal glandular cells	122 NX
Prostate	122 NX

Basal keratinocytes	1442 NX
Skin	1442 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	15 NX
Heart muscle	15 NX

Cholangiocytes	94 NX
Liver	94 NX

Ciliated cells	261 NX
Lung	261 NX

Club cells	92 NX
Lung	92 NX

Collecting duct cells	194 NX
Kidney	194 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	196 NX
Kidney	196 NX

Ductal cells	126 NX
Pancreas	126 NX

Early spermatids	15 NX
Testis	15 NX

Endothelial cells	6 NX
Skin	278 NX
Lung	29 NX
Prostate	11 NX
Testis	9 NX
Heart muscle	5 NX
Eye	2 NX
Liver	0 NX
Pancreas	0 NX
Placenta	0 NX

Enterocytes	1 NX
Colon	3 NX
Rectum	2 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	120 NX
Pancreas	120 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	57 NX
Skin	195 NX
Lung	175 NX
Placenta	54 NX
Prostate	13 NX
Heart muscle	10 NX

Glandular cells	56 NX
Prostate	55 NX

Granulocytes	7 NX
Lung	14 NX
Colon	0 NX

Hepatocytes	2 NX
Liver	2 NX

Hofbauer cells	1 NX
Placenta	1 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	47 NX
Rectum	61 NX
Colon	34 NX

Ito cells	6 NX
Liver	6 NX

Kupffer cells	1 NX
Liver	1 NX

Late spermatids	68 NX
Testis	68 NX

Leydig cells	12 NX
Testis	12 NX

Macrophages	5 NX
Skin	184 NX
Prostate	14 NX
Lung	5 NX
Kidney	2 NX
Testis	1 NX
Pancreas	0 NX

Melanocytes	290 NX
Skin	290 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	4 NX
Rectum	17 NX
Colon	4 NX
Small intestine	2 NX

Muller glia cells	9 NX
Eye	9 NX

Pancreatic endocrine cells	138 NX
Pancreas	138 NX

Paneth cells	6 NX
Rectum	16 NX
Colon	6 NX
Small intestine	4 NX

Peritubular cells	15 NX
Testis	15 NX

Proximal tubular cells	4 NX
Kidney	4 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	14 NX
Skin	97 NX
Prostate	14 NX
Pancreas	8 NX
Heart muscle	5 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	16 NX
Testis	16 NX

Suprabasal keratinocytes	7442 NX
Skin	7442 NX

Syncytiotrophoblasts	2 NX
Placenta	2 NX

T-cells	5 NX
Skin	110 NX
Prostate	26 NX
Lung	20 NX
Kidney	5 NX
Colon	4 NX
Liver	3 NX

Undifferentiated cells	11 NX
Colon	21 NX
Rectum	18 NX
Small intestine	1 NX

Urothelial cells	73 NX
Prostate	73 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.