Cell type atlas - FDPS - The Human Protein Atlas

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FDPS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FDPS
Gene descriptionⁱ Full gene name according to HGNC.	Farnesyl diphosphate synthase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HBEC3-KT)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	69 NX
Lung	69 NX

Alveolar cells type 2	144 NX
Lung	144 NX

B-cells	65 NX
Liver	106 NX
Colon	72 NX
Kidney	58 NX

Basal glandular cells	79 NX
Prostate	79 NX

Basal keratinocytes	33 NX
Skin	33 NX

Bipolar cells	66 NX
Eye	66 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	107 NX
Liver	107 NX

Ciliated cells	86 NX
Lung	86 NX

Club cells	83 NX
Lung	83 NX

Collecting duct cells	51 NX
Kidney	51 NX

Cone photoreceptor cells	59 NX
Eye	59 NX

Cytotrophoblasts	177 NX
Placenta	177 NX

Distal tubular cells	116 NX
Kidney	116 NX

Ductal cells	154 NX
Pancreas	154 NX

Early spermatids	171 NX
Testis	171 NX

Endothelial cells	113 NX
Placenta	352 NX
Pancreas	322 NX
Testis	202 NX
Prostate	124 NX
Liver	119 NX
Lung	102 NX
Skin	87 NX
Eye	76 NX
Heart muscle	19 NX

Enterocytes	197 NX
Colon	454 NX
Small intestine	161 NX
Rectum	82 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	286 NX
Pancreas	286 NX

Extravillous trophoblasts	163 NX
Placenta	163 NX

Fibroblasts	57 NX
Placenta	126 NX
Prostate	58 NX
Skin	45 NX
Lung	26 NX
Heart muscle	4 NX

Glandular cells	90 NX
Prostate	89 NX

Granulocytes	62 NX
Colon	83 NX
Lung	42 NX

Hepatocytes	112 NX
Liver	112 NX

Hofbauer cells	96 NX
Placenta	96 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	69 NX
Rectum	73 NX
Colon	65 NX

Ito cells	134 NX
Liver	134 NX

Kupffer cells	58 NX
Liver	58 NX

Late spermatids	52 NX
Testis	52 NX

Leydig cells	56 NX
Testis	56 NX

Macrophages	56 NX
Pancreas	91 NX
Kidney	67 NX
Testis	64 NX
Lung	56 NX
Prostate	56 NX
Skin	43 NX

Melanocytes	91 NX
Skin	91 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	217 NX
Pancreas	217 NX

Mucus-secreting cells	75 NX
Colon	201 NX
Small intestine	100 NX
Rectum	64 NX

Muller glia cells	75 NX
Eye	75 NX

Pancreatic endocrine cells	195 NX
Pancreas	195 NX

Paneth cells	144 NX
Colon	645 NX
Small intestine	144 NX
Rectum	74 NX

Peritubular cells	66 NX
Testis	66 NX

Proximal tubular cells	114 NX
Kidney	114 NX

Rod photoreceptor cells	78 NX
Eye	78 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	64 NX
Pancreas	204 NX
Prostate	72 NX
Skin	61 NX
Heart muscle	10 NX

Spermatocytes	42 NX
Testis	42 NX

Spermatogonia	16 NX
Testis	16 NX

Suprabasal keratinocytes	52 NX
Skin	52 NX

Syncytiotrophoblasts	120 NX
Placenta	120 NX

T-cells	78 NX
Kidney	108 NX
Liver	104 NX
Lung	76 NX
Colon	70 NX
Skin	65 NX
Prostate	35 NX

Undifferentiated cells	106 NX
Colon	249 NX
Small intestine	105 NX
Rectum	74 NX

Urothelial cells	110 NX
Prostate	110 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.