Cell type atlas - ADAR - The Human Protein Atlas

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ADAR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADAR
Gene descriptionⁱ Full gene name according to HGNC.	Adenosine deaminase, RNA specific
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	77 NX
Lung	77 NX

Alveolar cells type 2	46 NX
Lung	46 NX

B-cells	72 NX
Colon	112 NX
Liver	72 NX
Kidney	49 NX

Basal glandular cells	33 NX
Prostate	33 NX

Basal keratinocytes	30 NX
Skin	30 NX

Bipolar cells	90 NX
Eye	90 NX

Cardiomyocytes	16 NX
Heart muscle	16 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	42 NX
Lung	42 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	90 NX
Eye	90 NX

Cytotrophoblasts	34 NX
Placenta	34 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	44 NX
Pancreas	44 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	83 NX
Testis	93 NX
Heart muscle	91 NX
Eye	89 NX
Liver	83 NX
Prostate	82 NX
Lung	73 NX
Skin	72 NX
Placenta	60 NX
Pancreas	54 NX

Enterocytes	68 NX
Rectum	72 NX
Small intestine	69 NX
Colon	52 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	58 NX
Pancreas	58 NX

Extravillous trophoblasts	42 NX
Placenta	42 NX

Fibroblasts	40 NX
Prostate	57 NX
Lung	47 NX
Heart muscle	42 NX
Placenta	41 NX
Skin	36 NX

Glandular cells	48 NX
Prostate	48 NX

Granulocytes	61 NX
Colon	74 NX
Lung	49 NX

Hepatocytes	79 NX
Liver	79 NX

Hofbauer cells	47 NX
Placenta	47 NX

Horizontal cells	159 NX
Eye	159 NX

Intestinal endocrine cells	61 NX
Rectum	70 NX
Colon	51 NX

Ito cells	78 NX
Liver	78 NX

Kupffer cells	80 NX
Liver	80 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	68 NX
Testis	68 NX

Macrophages	57 NX
Kidney	77 NX
Testis	72 NX
Lung	68 NX
Pancreas	52 NX
Skin	42 NX
Prostate	39 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	69 NX
Pancreas	69 NX

Mucus-secreting cells	55 NX
Small intestine	76 NX
Rectum	49 NX
Colon	25 NX

Muller glia cells	47 NX
Eye	47 NX

Pancreatic endocrine cells	58 NX
Pancreas	58 NX

Paneth cells	54 NX
Small intestine	77 NX
Rectum	54 NX
Colon	40 NX

Peritubular cells	56 NX
Testis	56 NX

Proximal tubular cells	36 NX
Kidney	36 NX

Rod photoreceptor cells	82 NX
Eye	82 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	37 NX
Skin	43 NX
Prostate	38 NX
Heart muscle	37 NX
Pancreas	36 NX

Spermatocytes	12 NX
Testis	12 NX

Spermatogonia	23 NX
Testis	23 NX

Suprabasal keratinocytes	35 NX
Skin	35 NX

Syncytiotrophoblasts	26 NX
Placenta	26 NX

T-cells	58 NX
Colon	109 NX
Liver	64 NX
Kidney	63 NX
Skin	58 NX
Lung	45 NX
Prostate	22 NX

Undifferentiated cells	48 NX
Rectum	49 NX
Small intestine	48 NX
Colon	43 NX

Urothelial cells	41 NX
Prostate	41 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.