Cell type atlas - PCSK7 - The Human Protein Atlas

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PCSK7

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PCSK7
Gene descriptionⁱ Full gene name according to HGNC.	Proprotein convertase subtilisin/kexin type 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	46 NX
Lung	46 NX

B-cells	101 NX
Kidney	120 NX
Colon	118 NX
Liver	57 NX

Basal glandular cells	39 NX
Prostate	39 NX

Basal keratinocytes	62 NX
Skin	62 NX

Bipolar cells	109 NX
Eye	109 NX

Cardiomyocytes	6 NX
Heart muscle	6 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	38 NX
Lung	38 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	232 NX
Eye	232 NX

Cytotrophoblasts	40 NX
Placenta	39 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	25 NX
Pancreas	25 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	37 NX
Liver	133 NX
Skin	57 NX
Eye	47 NX
Placenta	41 NX
Prostate	37 NX
Lung	35 NX
Testis	31 NX
Heart muscle	17 NX
Pancreas	11 NX

Enterocytes	105 NX
Rectum	213 NX
Colon	160 NX
Small intestine	89 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	48 NX
Pancreas	48 NX

Extravillous trophoblasts	31 NX
Placenta	31 NX

Fibroblasts	39 NX
Skin	52 NX
Placenta	43 NX
Prostate	35 NX
Lung	30 NX
Heart muscle	20 NX

Glandular cells	31 NX
Prostate	31 NX

Granulocytes	32 NX
Lung	47 NX
Colon	18 NX

Hepatocytes	24 NX
Liver	24 NX

Hofbauer cells	28 NX
Placenta	28 NX

Horizontal cells	83 NX
Eye	83 NX

Intestinal endocrine cells	60 NX
Rectum	66 NX
Colon	54 NX

Ito cells	73 NX
Liver	73 NX

Kupffer cells	48 NX
Liver	48 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	31 NX
Testis	31 NX

Macrophages	50 NX
Skin	75 NX
Lung	65 NX
Kidney	52 NX
Testis	40 NX
Prostate	35 NX
Pancreas	26 NX

Melanocytes	51 NX
Skin	51 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	29 NX
Pancreas	29 NX

Mucus-secreting cells	75 NX
Small intestine	102 NX
Rectum	80 NX
Colon	70 NX

Muller glia cells	25 NX
Eye	25 NX

Pancreatic endocrine cells	53 NX
Pancreas	53 NX

Paneth cells	134 NX
Colon	156 NX
Rectum	134 NX
Small intestine	67 NX

Peritubular cells	37 NX
Testis	37 NX

Proximal tubular cells	6 NX
Kidney	6 NX

Rod photoreceptor cells	164 NX
Eye	164 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	70 NX
Skin	300 NX
Prostate	70 NX
Pancreas	46 NX
Heart muscle	43 NX

Spermatocytes	44 NX
Testis	44 NX

Spermatogonia	23 NX
Testis	23 NX

Suprabasal keratinocytes	82 NX
Skin	82 NX

Syncytiotrophoblasts	52 NX
Placenta	52 NX

T-cells	172 NX
Liver	221 NX
Skin	191 NX
Kidney	172 NX
Colon	117 NX
Lung	111 NX
Prostate	39 NX

Undifferentiated cells	89 NX
Rectum	124 NX
Colon	101 NX
Small intestine	53 NX

Urothelial cells	51 NX
Prostate	51 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.