Cell type atlas - TFF3 - The Human Protein Atlas

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TFF3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TFF3
Gene descriptionⁱ Full gene name according to HGNC.	Trefoil factor 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Mucus-secreting cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (MCF7, OE19, SCLC-21H, T-47d, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Mucus-secreting cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	22 NX
Lung	22 NX

B-cells	1 NX
Colon	134 NX
Liver	1 NX
Kidney	0 NX

Basal glandular cells	17 NX
Prostate	17 NX

Basal keratinocytes	37 NX
Skin	37 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	1111 NX
Liver	1111 NX

Ciliated cells	464 NX
Lung	464 NX

Club cells	316 NX
Lung	316 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	0 NX
Placenta	0 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	9 NX
Pancreas	9 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	51 NX
Skin	2418 NX
Lung	1951 NX
Liver	70 NX
Testis	69 NX
Placenta	63 NX
Heart muscle	46 NX
Prostate	28 NX
Pancreas	4 NX
Eye	2 NX

Enterocytes	1768 NX
Rectum	2912 NX
Small intestine	2347 NX
Colon	738 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	62 NX
Pancreas	62 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	20 NX
Skin	31 NX
Heart muscle	29 NX
Prostate	20 NX
Lung	12 NX
Placenta	4 NX

Glandular cells	103 NX
Prostate	103 NX

Granulocytes	61 NX
Colon	119 NX
Lung	2 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	2 NX
Placenta	2 NX

Horizontal cells	5 NX
Eye	5 NX

Intestinal endocrine cells	741 NX
Rectum	850 NX
Colon	632 NX

Ito cells	83 NX
Liver	83 NX

Kupffer cells	3 NX
Liver	3 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	2 NX
Testis	2 NX

Macrophages	3 NX
Skin	27 NX
Lung	8 NX
Testis	1 NX
Pancreas	0 NX
Kidney	0 NX
Prostate	0 NX

Melanocytes	91 NX
Skin	91 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	0 NX
Pancreas	0 NX

Mucus-secreting cells	36697 NX
Small intestine	57254 NX
Rectum	53697 NX
Colon	4066 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	28 NX
Pancreas	28 NX

Paneth cells	1779 NX
Small intestine	1852 NX
Colon	1779 NX
Rectum	1402 NX

Peritubular cells	7 NX
Testis	7 NX

Proximal tubular cells	0 NX
Kidney	0 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	6 NX
Skin	18 NX
Prostate	6 NX
Heart muscle	5 NX
Pancreas	0 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	0 NX
Testis	0 NX

Suprabasal keratinocytes	34 NX
Skin	34 NX

Syncytiotrophoblasts	1 NX
Placenta	1 NX

T-cells	1 NX
Colon	137 NX
Skin	14 NX
Lung	12 NX
Liver	1 NX
Prostate	0 NX
Kidney	0 NX

Undifferentiated cells	1243 NX
Rectum	1331 NX
Small intestine	1331 NX
Colon	624 NX

Urothelial cells	30 NX
Prostate	30 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.