Cell type atlas - CTBP1 - The Human Protein Atlas

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CTBP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CTBP1
Gene descriptionⁱ Full gene name according to HGNC.	C-terminal binding protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	51 NX
Liver	86 NX
Kidney	31 NX
Colon	28 NX

Basal glandular cells	19 NX
Prostate	19 NX

Basal keratinocytes	30 NX
Skin	30 NX

Bipolar cells	28 NX
Eye	28 NX

Cardiomyocytes	46 NX
Heart muscle	46 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	19 NX
Lung	19 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	22 NX
Placenta	22 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	27 NX
Pancreas	27 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	34 NX
Liver	63 NX
Heart muscle	42 NX
Eye	38 NX
Skin	38 NX
Testis	34 NX
Placenta	34 NX
Prostate	23 NX
Lung	18 NX
Pancreas	14 NX

Enterocytes	47 NX
Rectum	54 NX
Colon	48 NX
Small intestine	36 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	35 NX
Pancreas	35 NX

Extravillous trophoblasts	27 NX
Placenta	27 NX

Fibroblasts	28 NX
Skin	46 NX
Lung	28 NX
Placenta	26 NX
Heart muscle	25 NX
Prostate	20 NX

Glandular cells	33 NX
Prostate	33 NX

Granulocytes	23 NX
Lung	28 NX
Colon	18 NX

Hepatocytes	79 NX
Liver	79 NX

Hofbauer cells	37 NX
Placenta	37 NX

Horizontal cells	38 NX
Eye	38 NX

Intestinal endocrine cells	44 NX
Rectum	45 NX
Colon	44 NX

Ito cells	49 NX
Liver	49 NX

Kupffer cells	64 NX
Liver	64 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	42 NX
Testis	42 NX

Macrophages	35 NX
Kidney	41 NX
Testis	36 NX
Prostate	35 NX
Skin	32 NX
Lung	31 NX
Pancreas	30 NX

Melanocytes	44 NX
Skin	44 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	24 NX
Pancreas	24 NX

Mucus-secreting cells	42 NX
Rectum	43 NX
Small intestine	42 NX
Colon	39 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	38 NX
Pancreas	38 NX

Paneth cells	32 NX
Rectum	49 NX
Small intestine	32 NX
Colon	17 NX

Peritubular cells	34 NX
Testis	34 NX

Proximal tubular cells	29 NX
Kidney	29 NX

Rod photoreceptor cells	16 NX
Eye	16 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	27 NX
Heart muscle	29 NX
Pancreas	27 NX
Skin	25 NX
Prostate	20 NX

Spermatocytes	6 NX
Testis	6 NX

Spermatogonia	15 NX
Testis	15 NX

Suprabasal keratinocytes	33 NX
Skin	33 NX

Syncytiotrophoblasts	17 NX
Placenta	17 NX

T-cells	40 NX
Liver	85 NX
Skin	40 NX
Lung	39 NX
Kidney	38 NX
Colon	32 NX
Prostate	18 NX

Undifferentiated cells	51 NX
Rectum	52 NX
Colon	49 NX
Small intestine	44 NX

Urothelial cells	24 NX
Prostate	24 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.