Cell type atlas - NAE1 - The Human Protein Atlas

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NAE1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NAE1
Gene descriptionⁱ Full gene name according to HGNC.	NEDD8 activating enzyme E1 subunit 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatogonia)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatogonia)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	25 NX
Lung	25 NX

B-cells	24 NX
Kidney	31 NX
Liver	22 NX
Colon	18 NX

Basal glandular cells	55 NX
Prostate	55 NX

Basal keratinocytes	29 NX
Skin	29 NX

Bipolar cells	48 NX
Eye	48 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	38 NX
Lung	38 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	30 NX
Kidney	30 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	87 NX
Placenta	87 NX

Distal tubular cells	33 NX
Kidney	33 NX

Ductal cells	59 NX
Pancreas	59 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	23 NX
Pancreas	90 NX
Placenta	33 NX
Prostate	29 NX
Testis	29 NX
Heart muscle	26 NX
Eye	22 NX
Skin	19 NX
Liver	14 NX
Lung	9 NX

Enterocytes	27 NX
Rectum	32 NX
Small intestine	30 NX
Colon	16 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	53 NX
Pancreas	53 NX

Extravillous trophoblasts	55 NX
Placenta	55 NX

Fibroblasts	37 NX
Lung	44 NX
Placenta	43 NX
Heart muscle	40 NX
Prostate	35 NX
Skin	25 NX

Glandular cells	37 NX
Prostate	37 NX

Granulocytes	34 NX
Lung	49 NX
Colon	18 NX

Hepatocytes	19 NX
Liver	19 NX

Hofbauer cells	25 NX
Placenta	25 NX

Horizontal cells	48 NX
Eye	48 NX

Intestinal endocrine cells	22 NX
Rectum	31 NX
Colon	14 NX

Ito cells	21 NX
Liver	21 NX

Kupffer cells	12 NX
Liver	12 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	45 NX
Testis	45 NX

Macrophages	16 NX
Pancreas	40 NX
Testis	16 NX
Skin	16 NX
Kidney	15 NX
Prostate	13 NX
Lung	12 NX

Melanocytes	47 NX
Skin	47 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	28 NX
Small intestine	38 NX
Rectum	28 NX
Colon	26 NX

Muller glia cells	59 NX
Eye	59 NX

Pancreatic endocrine cells	52 NX
Pancreas	52 NX

Paneth cells	83 NX
Small intestine	161 NX
Rectum	83 NX
Colon	69 NX

Peritubular cells	51 NX
Testis	51 NX

Proximal tubular cells	41 NX
Kidney	41 NX

Rod photoreceptor cells	34 NX
Eye	34 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	50 NX
Pancreas	64 NX
Heart muscle	61 NX
Skin	37 NX
Prostate	28 NX

Spermatocytes	121 NX
Testis	121 NX

Spermatogonia	205 NX
Testis	205 NX

Suprabasal keratinocytes	28 NX
Skin	28 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	32 NX
Kidney	46 NX
Colon	33 NX
Lung	32 NX
Liver	30 NX
Prostate	26 NX
Skin	25 NX

Undifferentiated cells	34 NX
Small intestine	53 NX
Rectum	32 NX
Colon	32 NX

Urothelial cells	41 NX
Prostate	41 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.