Cell type atlas - AMFR - The Human Protein Atlas

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AMFR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AMFR
Gene descriptionⁱ Full gene name according to HGNC.	Autocrine motility factor receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	7 NX
Lung	7 NX

B-cells	29 NX
Liver	34 NX
Kidney	31 NX
Colon	18 NX

Basal glandular cells	15 NX
Prostate	15 NX

Basal keratinocytes	23 NX
Skin	23 NX

Bipolar cells	17 NX
Eye	17 NX

Cardiomyocytes	18 NX
Heart muscle	18 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	1 NX
Lung	1 NX

Club cells	9 NX
Lung	9 NX

Collecting duct cells	94 NX
Kidney	94 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	21 NX
Placenta	21 NX

Distal tubular cells	22 NX
Kidney	22 NX

Ductal cells	18 NX
Pancreas	18 NX

Early spermatids	124 NX
Testis	124 NX

Endothelial cells	20 NX
Prostate	27 NX
Liver	27 NX
Testis	25 NX
Eye	23 NX
Skin	20 NX
Lung	20 NX
Heart muscle	17 NX
Placenta	14 NX
Pancreas	14 NX

Enterocytes	38 NX
Rectum	69 NX
Small intestine	48 NX
Colon	27 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	6 NX
Placenta	6 NX

Fibroblasts	28 NX
Prostate	42 NX
Skin	32 NX
Placenta	25 NX
Heart muscle	24 NX
Lung	7 NX

Glandular cells	28 NX
Prostate	28 NX

Granulocytes	8 NX
Lung	16 NX
Colon	0 NX

Hepatocytes	146 NX
Liver	146 NX

Hofbauer cells	15 NX
Placenta	15 NX

Horizontal cells	30 NX
Eye	30 NX

Intestinal endocrine cells	24 NX
Rectum	37 NX
Colon	10 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	62 NX
Liver	62 NX

Late spermatids	81 NX
Testis	81 NX

Leydig cells	38 NX
Testis	38 NX

Macrophages	22 NX
Prostate	38 NX
Skin	26 NX
Testis	24 NX
Kidney	21 NX
Lung	21 NX
Pancreas	16 NX

Melanocytes	29 NX
Skin	29 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	15 NX
Pancreas	15 NX

Mucus-secreting cells	26 NX
Rectum	33 NX
Small intestine	22 NX
Colon	10 NX

Muller glia cells	45 NX
Eye	45 NX

Pancreatic endocrine cells	27 NX
Pancreas	27 NX

Paneth cells	21 NX
Rectum	31 NX
Small intestine	21 NX
Colon	17 NX

Peritubular cells	32 NX
Testis	32 NX

Proximal tubular cells	43 NX
Kidney	43 NX

Rod photoreceptor cells	41 NX
Eye	41 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	27 NX
Skin	31 NX
Prostate	27 NX
Pancreas	18 NX
Heart muscle	14 NX

Spermatocytes	32 NX
Testis	32 NX

Spermatogonia	11 NX
Testis	11 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	20 NX
Placenta	20 NX

T-cells	15 NX
Skin	26 NX
Kidney	18 NX
Colon	18 NX
Liver	14 NX
Prostate	13 NX
Lung	12 NX

Undifferentiated cells	20 NX
Rectum	25 NX
Small intestine	20 NX
Colon	15 NX

Urothelial cells	17 NX
Prostate	17 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.