Cell type atlas - NBL1 - The Human Protein Atlas

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NBL1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NBL1
Gene descriptionⁱ Full gene name according to HGNC.	Neuroblastoma 1, DAN family BMP antagonist
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Enterocytes, Leydig cells, Peritubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (memory CD4 T-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff, HSkMC, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Enterocytes, Leydig cells, Peritubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	3 NX
Lung	3 NX

Alveolar cells type 2	3 NX
Lung	3 NX

B-cells	3 NX
Colon	9 NX
Kidney	5 NX
Liver	1 NX

Basal glandular cells	208 NX
Prostate	208 NX

Basal keratinocytes	155 NX
Skin	155 NX

Bipolar cells	17 NX
Eye	17 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	7 NX
Lung	7 NX

Club cells	6 NX
Lung	6 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	40 NX
Pancreas	40 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	106 NX
Heart muscle	183 NX
Skin	140 NX
Testis	127 NX
Eye	106 NX
Prostate	97 NX
Liver	52 NX
Pancreas	22 NX
Placenta	21 NX
Lung	15 NX

Enterocytes	364 NX
Colon	368 NX
Small intestine	345 NX
Rectum	305 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	7 NX
Pancreas	7 NX

Extravillous trophoblasts	2 NX
Placenta	2 NX

Fibroblasts	175 NX
Prostate	550 NX
Skin	371 NX
Heart muscle	208 NX
Lung	35 NX
Placenta	9 NX

Glandular cells	258 NX
Prostate	258 NX

Granulocytes	14 NX
Colon	28 NX
Lung	0 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	41 NX
Placenta	41 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	52 NX
Rectum	54 NX
Colon	51 NX

Ito cells	31 NX
Liver	31 NX

Kupffer cells	2 NX
Liver	2 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	358 NX
Testis	358 NX

Macrophages	6 NX
Skin	54 NX
Prostate	30 NX
Testis	9 NX
Lung	2 NX
Pancreas	2 NX
Kidney	1 NX

Melanocytes	57 NX
Skin	57 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	10 NX
Pancreas	10 NX

Mucus-secreting cells	185 NX
Colon	289 NX
Small intestine	188 NX
Rectum	179 NX

Muller glia cells	6 NX
Eye	6 NX

Pancreatic endocrine cells	59 NX
Pancreas	59 NX

Paneth cells	180 NX
Colon	487 NX
Rectum	180 NX
Small intestine	172 NX

Peritubular cells	336 NX
Testis	336 NX

Proximal tubular cells	17 NX
Kidney	17 NX

Rod photoreceptor cells	8 NX
Eye	8 NX

Sertoli cells	129 NX
Testis	129 NX

Smooth muscle cells	194 NX
Prostate	268 NX
Heart muscle	199 NX
Pancreas	194 NX
Skin	134 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	4 NX
Testis	4 NX

Suprabasal keratinocytes	177 NX
Skin	177 NX

Syncytiotrophoblasts	1 NX
Placenta	1 NX

T-cells	11 NX
Colon	99 NX
Skin	92 NX
Prostate	74 NX
Kidney	11 NX
Liver	4 NX
Lung	0 NX

Undifferentiated cells	167 NX
Colon	262 NX
Rectum	190 NX
Small intestine	146 NX

Urothelial cells	178 NX
Prostate	178 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.