Cell type atlas - DUSP23 - The Human Protein Atlas

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DUSP23

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DUSP23
Gene descriptionⁱ Full gene name according to HGNC.	Dual specificity phosphatase 23
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Exocrine glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HSkMC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Exocrine glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	66 NX
Lung	66 NX

B-cells	25 NX
Kidney	54 NX
Liver	25 NX
Colon	21 NX

Basal glandular cells	98 NX
Prostate	98 NX

Basal keratinocytes	66 NX
Skin	66 NX

Bipolar cells	8 NX
Eye	8 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	94 NX
Liver	94 NX

Ciliated cells	39 NX
Lung	39 NX

Club cells	83 NX
Lung	83 NX

Collecting duct cells	49 NX
Kidney	49 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	14 NX
Placenta	14 NX

Distal tubular cells	222 NX
Kidney	222 NX

Ductal cells	149 NX
Pancreas	149 NX

Early spermatids	40 NX
Testis	40 NX

Endothelial cells	154 NX
Liver	252 NX
Prostate	215 NX
Placenta	209 NX
Testis	181 NX
Skin	127 NX
Heart muscle	107 NX
Eye	46 NX
Lung	35 NX
Pancreas	29 NX

Enterocytes	106 NX
Small intestine	121 NX
Colon	100 NX
Rectum	91 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	394 NX
Pancreas	394 NX

Extravillous trophoblasts	20 NX
Placenta	20 NX

Fibroblasts	32 NX
Placenta	56 NX
Skin	34 NX
Lung	31 NX
Heart muscle	30 NX
Prostate	21 NX

Glandular cells	95 NX
Prostate	95 NX

Granulocytes	53 NX
Colon	55 NX
Lung	51 NX

Hepatocytes	220 NX
Liver	220 NX

Hofbauer cells	155 NX
Placenta	155 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	34 NX
Rectum	37 NX
Colon	31 NX

Ito cells	66 NX
Liver	66 NX

Kupffer cells	87 NX
Liver	87 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	25 NX
Testis	25 NX

Macrophages	95 NX
Kidney	193 NX
Pancreas	117 NX
Prostate	104 NX
Skin	88 NX
Testis	83 NX
Lung	76 NX

Melanocytes	41 NX
Skin	41 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	102 NX
Colon	128 NX
Rectum	102 NX
Small intestine	83 NX

Muller glia cells	60 NX
Eye	60 NX

Pancreatic endocrine cells	259 NX
Pancreas	259 NX

Paneth cells	102 NX
Rectum	123 NX
Small intestine	102 NX
Colon	81 NX

Peritubular cells	15 NX
Testis	15 NX

Proximal tubular cells	621 NX
Kidney	621 NX

Rod photoreceptor cells	7 NX
Eye	7 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	32 NX
Pancreas	54 NX
Heart muscle	36 NX
Skin	29 NX
Prostate	21 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	13 NX
Testis	13 NX

Suprabasal keratinocytes	65 NX
Skin	65 NX

Syncytiotrophoblasts	5 NX
Placenta	5 NX

T-cells	44 NX
Kidney	106 NX
Lung	52 NX
Liver	45 NX
Colon	38 NX
Skin	35 NX
Prostate	31 NX

Undifferentiated cells	92 NX
Rectum	107 NX
Small intestine	92 NX
Colon	80 NX

Urothelial cells	102 NX
Prostate	102 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.