Cell type atlas - FAIM - The Human Protein Atlas

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FAIM

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAIM
Gene descriptionⁱ Full gene name according to HGNC.	Fas apoptotic inhibitory molecule
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	16 NX
Lung	16 NX

B-cells	9 NX
Kidney	27 NX
Colon	9 NX
Liver	5 NX

Basal glandular cells	24 NX
Prostate	24 NX

Basal keratinocytes	10 NX
Skin	10 NX

Bipolar cells	27 NX
Eye	27 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	64 NX
Liver	64 NX

Ciliated cells	87 NX
Lung	87 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	37 NX
Placenta	37 NX

Distal tubular cells	27 NX
Kidney	27 NX

Ductal cells	49 NX
Pancreas	49 NX

Early spermatids	10 NX
Testis	10 NX

Endothelial cells	11 NX
Pancreas	29 NX
Eye	26 NX
Liver	18 NX
Heart muscle	15 NX
Skin	10 NX
Placenta	10 NX
Testis	9 NX
Prostate	9 NX
Lung	0 NX

Enterocytes	2 NX
Rectum	6 NX
Colon	2 NX
Small intestine	1 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	44 NX
Pancreas	44 NX

Extravillous trophoblasts	25 NX
Placenta	25 NX

Fibroblasts	18 NX
Placenta	20 NX
Skin	16 NX
Heart muscle	16 NX
Prostate	8 NX
Lung	4 NX

Glandular cells	19 NX
Prostate	19 NX

Granulocytes	40 NX
Colon	46 NX
Lung	35 NX

Hepatocytes	10 NX
Liver	10 NX

Hofbauer cells	25 NX
Placenta	25 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	20 NX
Rectum	31 NX
Colon	10 NX

Ito cells	9 NX
Liver	9 NX

Kupffer cells	4 NX
Liver	4 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	16 NX
Testis	16 NX

Macrophages	6 NX
Pancreas	12 NX
Testis	8 NX
Prostate	6 NX
Lung	5 NX
Kidney	5 NX
Skin	4 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	8 NX
Rectum	11 NX
Colon	6 NX
Small intestine	5 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	31 NX
Pancreas	31 NX

Paneth cells	0 NX
Rectum	12 NX
Colon	0 NX
Small intestine	0 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	19 NX
Kidney	19 NX

Rod photoreceptor cells	190 NX
Eye	190 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	20 NX
Skin	23 NX
Prostate	21 NX
Heart muscle	20 NX
Pancreas	17 NX

Spermatocytes	17 NX
Testis	17 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	11 NX
Skin	11 NX

Syncytiotrophoblasts	12 NX
Placenta	12 NX

T-cells	10 NX
Prostate	22 NX
Lung	14 NX
Liver	11 NX
Kidney	8 NX
Colon	5 NX
Skin	5 NX

Undifferentiated cells	12 NX
Rectum	14 NX
Small intestine	12 NX
Colon	6 NX

Urothelial cells	23 NX
Prostate	23 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.