Cell type atlas - RER1 - The Human Protein Atlas

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RER1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RER1
Gene descriptionⁱ Full gene name according to HGNC.	Retention in endoplasmic reticulum sorting receptor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	60 NX
Lung	60 NX

Alveolar cells type 2	41 NX
Lung	41 NX

B-cells	58 NX
Liver	111 NX
Kidney	58 NX
Colon	58 NX

Basal glandular cells	72 NX
Prostate	72 NX

Basal keratinocytes	47 NX
Skin	47 NX

Bipolar cells	33 NX
Eye	33 NX

Cardiomyocytes	33 NX
Heart muscle	33 NX

Cholangiocytes	133 NX
Liver	133 NX

Ciliated cells	52 NX
Lung	52 NX

Club cells	30 NX
Lung	30 NX

Collecting duct cells	100 NX
Kidney	100 NX

Cone photoreceptor cells	31 NX
Eye	31 NX

Cytotrophoblasts	203 NX
Placenta	203 NX

Distal tubular cells	56 NX
Kidney	56 NX

Ductal cells	181 NX
Pancreas	181 NX

Early spermatids	360 NX
Testis	360 NX

Endothelial cells	59 NX
Placenta	115 NX
Pancreas	75 NX
Liver	74 NX
Eye	68 NX
Testis	59 NX
Skin	53 NX
Prostate	52 NX
Heart muscle	45 NX
Lung	26 NX

Enterocytes	206 NX
Small intestine	210 NX
Rectum	196 NX
Colon	163 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	227 NX
Pancreas	227 NX

Extravillous trophoblasts	262 NX
Placenta	262 NX

Fibroblasts	89 NX
Placenta	143 NX
Skin	85 NX
Prostate	64 NX
Lung	58 NX
Heart muscle	54 NX

Glandular cells	117 NX
Prostate	117 NX

Granulocytes	43 NX
Lung	49 NX
Colon	37 NX

Hepatocytes	226 NX
Liver	226 NX

Hofbauer cells	195 NX
Placenta	195 NX

Horizontal cells	35 NX
Eye	35 NX

Intestinal endocrine cells	35 NX
Colon	37 NX
Rectum	33 NX

Ito cells	84 NX
Liver	84 NX

Kupffer cells	103 NX
Liver	103 NX

Late spermatids	329 NX
Testis	329 NX

Leydig cells	77 NX
Testis	77 NX

Macrophages	85 NX
Pancreas	211 NX
Kidney	112 NX
Testis	90 NX
Skin	87 NX
Prostate	81 NX
Lung	73 NX

Melanocytes	59 NX
Skin	59 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	130 NX
Pancreas	130 NX

Mucus-secreting cells	125 NX
Colon	185 NX
Small intestine	131 NX
Rectum	105 NX

Muller glia cells	71 NX
Eye	71 NX

Pancreatic endocrine cells	204 NX
Pancreas	204 NX

Paneth cells	136 NX
Colon	256 NX
Rectum	136 NX
Small intestine	133 NX

Peritubular cells	72 NX
Testis	72 NX

Proximal tubular cells	98 NX
Kidney	98 NX

Rod photoreceptor cells	50 NX
Eye	50 NX

Sertoli cells	110 NX
Testis	110 NX

Smooth muscle cells	61 NX
Pancreas	265 NX
Heart muscle	84 NX
Prostate	61 NX
Skin	60 NX

Spermatocytes	192 NX
Testis	192 NX

Spermatogonia	119 NX
Testis	119 NX

Suprabasal keratinocytes	59 NX
Skin	59 NX

Syncytiotrophoblasts	391 NX
Placenta	391 NX

T-cells	77 NX
Kidney	91 NX
Liver	83 NX
Colon	77 NX
Skin	75 NX
Prostate	57 NX
Lung	55 NX

Undifferentiated cells	139 NX
Colon	167 NX
Small intestine	147 NX
Rectum	125 NX

Urothelial cells	109 NX
Prostate	109 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.