Cell type atlas - UBE2L6 - The Human Protein Atlas

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UBE2L6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBE2L6
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin conjugating enzyme E2 L6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	17 NX
Lung	17 NX

B-cells	54 NX
Colon	82 NX
Kidney	67 NX
Liver	37 NX

Basal glandular cells	23 NX
Prostate	23 NX

Basal keratinocytes	21 NX
Skin	21 NX

Bipolar cells	10 NX
Eye	10 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	27 NX
Lung	27 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	3 NX
Placenta	3 NX

Distal tubular cells	55 NX
Kidney	55 NX

Ductal cells	69 NX
Pancreas	69 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	47 NX
Placenta	97 NX
Testis	89 NX
Heart muscle	85 NX
Skin	49 NX
Lung	47 NX
Prostate	46 NX
Eye	43 NX
Pancreas	43 NX
Liver	34 NX

Enterocytes	23 NX
Small intestine	38 NX
Rectum	8 NX
Colon	6 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	57 NX
Pancreas	57 NX

Extravillous trophoblasts	31 NX
Placenta	31 NX

Fibroblasts	38 NX
Placenta	43 NX
Skin	38 NX
Prostate	33 NX
Heart muscle	33 NX
Lung	18 NX

Glandular cells	34 NX
Prostate	34 NX

Granulocytes	53 NX
Colon	64 NX
Lung	42 NX

Hepatocytes	27 NX
Liver	27 NX

Hofbauer cells	148 NX
Placenta	148 NX

Horizontal cells	13 NX
Eye	13 NX

Intestinal endocrine cells	23 NX
Colon	27 NX
Rectum	19 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	55 NX
Liver	55 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	45 NX
Testis	45 NX

Macrophages	69 NX
Kidney	135 NX
Lung	88 NX
Prostate	73 NX
Pancreas	70 NX
Testis	68 NX
Skin	38 NX

Melanocytes	9 NX
Skin	9 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	44 NX
Pancreas	44 NX

Mucus-secreting cells	30 NX
Colon	47 NX
Rectum	31 NX
Small intestine	28 NX

Muller glia cells	32 NX
Eye	32 NX

Pancreatic endocrine cells	45 NX
Pancreas	45 NX

Paneth cells	32 NX
Small intestine	74 NX
Colon	32 NX
Rectum	26 NX

Peritubular cells	32 NX
Testis	32 NX

Proximal tubular cells	20 NX
Kidney	20 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	41 NX
Pancreas	54 NX
Heart muscle	45 NX
Skin	30 NX
Prostate	21 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	3 NX
Placenta	3 NX

T-cells	75 NX
Kidney	115 NX
Liver	78 NX
Colon	75 NX
Lung	53 NX
Skin	48 NX
Prostate	22 NX

Undifferentiated cells	22 NX
Colon	27 NX
Small intestine	26 NX
Rectum	10 NX

Urothelial cells	25 NX
Prostate	25 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.