Cell type atlas - UQCRB - The Human Protein Atlas

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UQCRB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UQCRB
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquinol-cytochrome c reductase binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	414 NX
Lung	414 NX

Alveolar cells type 2	523 NX
Lung	523 NX

B-cells	696 NX
Liver	858 NX
Kidney	664 NX
Colon	475 NX

Basal glandular cells	388 NX
Prostate	388 NX

Basal keratinocytes	269 NX
Skin	269 NX

Bipolar cells	266 NX
Eye	266 NX

Cardiomyocytes	4932 NX
Heart muscle	4932 NX

Cholangiocytes	861 NX
Liver	861 NX

Ciliated cells	515 NX
Lung	515 NX

Club cells	513 NX
Lung	513 NX

Collecting duct cells	316 NX
Kidney	316 NX

Cone photoreceptor cells	110 NX
Eye	110 NX

Cytotrophoblasts	495 NX
Placenta	495 NX

Distal tubular cells	2106 NX
Kidney	2106 NX

Ductal cells	666 NX
Pancreas	666 NX

Early spermatids	871 NX
Testis	871 NX

Endothelial cells	470 NX
Testis	740 NX
Liver	699 NX
Placenta	611 NX
Heart muscle	597 NX
Lung	470 NX
Pancreas	426 NX
Skin	403 NX
Prostate	294 NX
Eye	259 NX

Enterocytes	871 NX
Small intestine	1013 NX
Rectum	779 NX
Colon	667 NX

Erythroid cells	210 NX
Liver	210 NX

Exocrine glandular cells	806 NX
Pancreas	806 NX

Extravillous trophoblasts	419 NX
Placenta	419 NX

Fibroblasts	464 NX
Heart muscle	1722 NX
Placenta	589 NX
Lung	550 NX
Skin	303 NX
Prostate	252 NX

Glandular cells	366 NX
Prostate	366 NX

Granulocytes	568 NX
Lung	630 NX
Colon	505 NX

Hepatocytes	867 NX
Liver	867 NX

Hofbauer cells	985 NX
Placenta	985 NX

Horizontal cells	119 NX
Eye	119 NX

Intestinal endocrine cells	702 NX
Rectum	810 NX
Colon	595 NX

Ito cells	585 NX
Liver	585 NX

Kupffer cells	1469 NX
Liver	1469 NX

Late spermatids	178 NX
Testis	178 NX

Leydig cells	800 NX
Testis	800 NX

Macrophages	759 NX
Testis	970 NX
Kidney	911 NX
Lung	776 NX
Skin	673 NX
Prostate	661 NX
Pancreas	615 NX

Melanocytes	778 NX
Skin	778 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	959 NX
Pancreas	959 NX

Mucus-secreting cells	915 NX
Rectum	1261 NX
Colon	979 NX
Small intestine	554 NX

Muller glia cells	234 NX
Eye	234 NX

Pancreatic endocrine cells	819 NX
Pancreas	819 NX

Paneth cells	855 NX
Rectum	972 NX
Colon	855 NX
Small intestine	743 NX

Peritubular cells	678 NX
Testis	678 NX

Proximal tubular cells	1659 NX
Kidney	1659 NX

Rod photoreceptor cells	303 NX
Eye	303 NX

Sertoli cells	530 NX
Testis	530 NX

Smooth muscle cells	609 NX
Heart muscle	843 NX
Skin	808 NX
Pancreas	609 NX
Prostate	559 NX

Spermatocytes	265 NX
Testis	265 NX

Spermatogonia	241 NX
Testis	241 NX

Suprabasal keratinocytes	254 NX
Skin	254 NX

Syncytiotrophoblasts	501 NX
Placenta	501 NX

T-cells	685 NX
Skin	943 NX
Liver	711 NX
Kidney	689 NX
Lung	590 NX
Prostate	554 NX
Colon	547 NX

Undifferentiated cells	974 NX
Rectum	1205 NX
Small intestine	808 NX
Colon	808 NX

Urothelial cells	502 NX
Prostate	502 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.