Cell type atlas - USP16 - The Human Protein Atlas

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USP16

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP16
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 16
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	80 NX
Lung	80 NX

Alveolar cells type 2	84 NX
Lung	84 NX

B-cells	99 NX
Colon	125 NX
Kidney	89 NX
Liver	89 NX

Basal glandular cells	107 NX
Prostate	107 NX

Basal keratinocytes	51 NX
Skin	51 NX

Bipolar cells	162 NX
Eye	162 NX

Cardiomyocytes	75 NX
Heart muscle	75 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	112 NX
Lung	112 NX

Club cells	88 NX
Lung	88 NX

Collecting duct cells	51 NX
Kidney	51 NX

Cone photoreceptor cells	84 NX
Eye	84 NX

Cytotrophoblasts	70 NX
Placenta	70 NX

Distal tubular cells	113 NX
Kidney	113 NX

Ductal cells	62 NX
Pancreas	62 NX

Early spermatids	399 NX
Testis	399 NX

Endothelial cells	41 NX
Prostate	69 NX
Eye	69 NX
Testis	55 NX
Placenta	55 NX
Pancreas	39 NX
Skin	39 NX
Liver	38 NX
Heart muscle	36 NX
Lung	35 NX

Enterocytes	72 NX
Colon	87 NX
Small intestine	67 NX
Rectum	66 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	103 NX
Pancreas	103 NX

Extravillous trophoblasts	66 NX
Placenta	66 NX

Fibroblasts	62 NX
Lung	75 NX
Placenta	70 NX
Heart muscle	70 NX
Prostate	62 NX
Skin	49 NX

Glandular cells	83 NX
Prostate	83 NX

Granulocytes	137 NX
Lung	163 NX
Colon	110 NX

Hepatocytes	78 NX
Liver	78 NX

Hofbauer cells	53 NX
Placenta	53 NX

Horizontal cells	68 NX
Eye	68 NX

Intestinal endocrine cells	79 NX
Colon	88 NX
Rectum	70 NX

Ito cells	46 NX
Liver	46 NX

Kupffer cells	55 NX
Liver	55 NX

Late spermatids	90 NX
Testis	90 NX

Leydig cells	81 NX
Testis	81 NX

Macrophages	60 NX
Testis	76 NX
Lung	71 NX
Kidney	67 NX
Prostate	55 NX
Skin	50 NX
Pancreas	37 NX

Melanocytes	59 NX
Skin	59 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	96 NX
Pancreas	96 NX

Mucus-secreting cells	65 NX
Colon	135 NX
Small intestine	71 NX
Rectum	58 NX

Muller glia cells	103 NX
Eye	103 NX

Pancreatic endocrine cells	78 NX
Pancreas	78 NX

Paneth cells	76 NX
Colon	118 NX
Rectum	76 NX
Small intestine	74 NX

Peritubular cells	82 NX
Testis	82 NX

Proximal tubular cells	61 NX
Kidney	61 NX

Rod photoreceptor cells	186 NX
Eye	186 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	71 NX
Prostate	90 NX
Heart muscle	90 NX
Pancreas	71 NX
Skin	49 NX

Spermatocytes	80 NX
Testis	80 NX

Spermatogonia	64 NX
Testis	64 NX

Suprabasal keratinocytes	56 NX
Skin	56 NX

Syncytiotrophoblasts	136 NX
Placenta	136 NX

T-cells	69 NX
Colon	139 NX
Prostate	118 NX
Lung	112 NX
Kidney	86 NX
Skin	66 NX
Liver	58 NX

Undifferentiated cells	70 NX
Colon	83 NX
Small intestine	70 NX
Rectum	68 NX

Urothelial cells	112 NX
Prostate	112 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.