Cell type atlas - GNAQ - The Human Protein Atlas

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GNAQ

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNAQ
Gene descriptionⁱ Full gene name according to HGNC.	G protein subunit alpha q
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	164 NX
Lung	164 NX

Alveolar cells type 2	71 NX
Lung	71 NX

B-cells	6 NX
Kidney	13 NX
Colon	6 NX
Liver	3 NX

Basal glandular cells	34 NX
Prostate	34 NX

Basal keratinocytes	42 NX
Skin	42 NX

Bipolar cells	30 NX
Eye	30 NX

Cardiomyocytes	6 NX
Heart muscle	6 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	43 NX
Lung	43 NX

Club cells	35 NX
Lung	35 NX

Collecting duct cells	73 NX
Kidney	73 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	39 NX
Placenta	39 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	28 NX
Pancreas	28 NX

Early spermatids	13 NX
Testis	13 NX

Endothelial cells	85 NX
Testis	149 NX
Heart muscle	132 NX
Prostate	100 NX
Skin	89 NX
Liver	85 NX
Eye	82 NX
Placenta	72 NX
Lung	50 NX
Pancreas	25 NX

Enterocytes	70 NX
Rectum	165 NX
Colon	76 NX
Small intestine	45 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	35 NX
Pancreas	35 NX

Extravillous trophoblasts	42 NX
Placenta	42 NX

Fibroblasts	43 NX
Skin	71 NX
Heart muscle	50 NX
Prostate	43 NX
Placenta	34 NX
Lung	22 NX

Glandular cells	51 NX
Prostate	51 NX

Granulocytes	50 NX
Colon	55 NX
Lung	44 NX

Hepatocytes	51 NX
Liver	51 NX

Hofbauer cells	48 NX
Placenta	48 NX

Horizontal cells	78 NX
Eye	78 NX

Intestinal endocrine cells	89 NX
Rectum	89 NX
Colon	88 NX

Ito cells	107 NX
Liver	107 NX

Kupffer cells	139 NX
Liver	139 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	37 NX
Testis	37 NX

Macrophages	93 NX
Testis	189 NX
Skin	136 NX
Prostate	97 NX
Kidney	77 NX
Lung	74 NX
Pancreas	63 NX

Melanocytes	46 NX
Skin	46 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	72 NX
Pancreas	72 NX

Mucus-secreting cells	91 NX
Rectum	104 NX
Small intestine	72 NX
Colon	64 NX

Muller glia cells	37 NX
Eye	37 NX

Pancreatic endocrine cells	44 NX
Pancreas	44 NX

Paneth cells	49 NX
Rectum	90 NX
Colon	49 NX
Small intestine	25 NX

Peritubular cells	49 NX
Testis	49 NX

Proximal tubular cells	35 NX
Kidney	35 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	40 NX
Prostate	45 NX
Skin	43 NX
Heart muscle	37 NX
Pancreas	24 NX

Spermatocytes	5 NX
Testis	5 NX

Spermatogonia	7 NX
Testis	7 NX

Suprabasal keratinocytes	19 NX
Skin	19 NX

Syncytiotrophoblasts	24 NX
Placenta	24 NX

T-cells	22 NX
Skin	48 NX
Lung	30 NX
Prostate	22 NX
Liver	20 NX
Colon	14 NX
Kidney	12 NX

Undifferentiated cells	67 NX
Rectum	87 NX
Colon	67 NX
Small intestine	43 NX

Urothelial cells	50 NX
Prostate	50 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.