Cell type atlas - NIFK - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NIFK

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NIFK
Gene descriptionⁱ Full gene name according to HGNC.	Nucleolar protein interacting with the FHA domain of MKI67
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	23 NX
Lung	23 NX

B-cells	49 NX
Colon	54 NX
Kidney	45 NX
Liver	36 NX

Basal glandular cells	91 NX
Prostate	91 NX

Basal keratinocytes	87 NX
Skin	87 NX

Bipolar cells	26 NX
Eye	26 NX

Cardiomyocytes	18 NX
Heart muscle	18 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	44 NX
Lung	44 NX

Club cells	65 NX
Lung	65 NX

Collecting duct cells	14 NX
Kidney	14 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	64 NX
Placenta	64 NX

Distal tubular cells	40 NX
Kidney	40 NX

Ductal cells	65 NX
Pancreas	65 NX

Early spermatids	10 NX
Testis	10 NX

Endothelial cells	42 NX
Placenta	72 NX
Lung	70 NX
Prostate	59 NX
Testis	48 NX
Skin	43 NX
Pancreas	39 NX
Liver	38 NX
Eye	16 NX
Heart muscle	14 NX

Enterocytes	15 NX
Small intestine	16 NX
Rectum	13 NX
Colon	12 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	39 NX
Pancreas	39 NX

Extravillous trophoblasts	70 NX
Placenta	70 NX

Fibroblasts	52 NX
Lung	165 NX
Prostate	70 NX
Placenta	53 NX
Skin	42 NX
Heart muscle	27 NX

Glandular cells	40 NX
Prostate	40 NX

Granulocytes	53 NX
Colon	55 NX
Lung	51 NX

Hepatocytes	31 NX
Liver	31 NX

Hofbauer cells	49 NX
Placenta	49 NX

Horizontal cells	13 NX
Eye	13 NX

Intestinal endocrine cells	27 NX
Colon	31 NX
Rectum	23 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	32 NX
Liver	32 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	53 NX
Testis	53 NX

Macrophages	41 NX
Testis	47 NX
Lung	44 NX
Kidney	41 NX
Skin	37 NX
Prostate	31 NX
Pancreas	26 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	45 NX
Pancreas	45 NX

Mucus-secreting cells	38 NX
Colon	45 NX
Rectum	40 NX
Small intestine	25 NX

Muller glia cells	45 NX
Eye	45 NX

Pancreatic endocrine cells	46 NX
Pancreas	46 NX

Paneth cells	21 NX
Rectum	42 NX
Small intestine	21 NX
Colon	14 NX

Peritubular cells	43 NX
Testis	43 NX

Proximal tubular cells	40 NX
Kidney	40 NX

Rod photoreceptor cells	38 NX
Eye	38 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	44 NX
Pancreas	93 NX
Prostate	74 NX
Skin	41 NX
Heart muscle	36 NX

Spermatocytes	55 NX
Testis	55 NX

Spermatogonia	72 NX
Testis	72 NX

Suprabasal keratinocytes	89 NX
Skin	89 NX

Syncytiotrophoblasts	41 NX
Placenta	41 NX

T-cells	39 NX
Kidney	62 NX
Lung	59 NX
Colon	39 NX
Liver	38 NX
Skin	35 NX
Prostate	31 NX

Undifferentiated cells	44 NX
Colon	87 NX
Small intestine	57 NX
Rectum	44 NX

Urothelial cells	94 NX
Prostate	94 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.