Cell type atlas - RHOC - The Human Protein Atlas

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RHOC

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RHOC
Gene descriptionⁱ Full gene name according to HGNC.	Ras homolog family member C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Pancreatic endocrine cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (non-classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Pancreatic endocrine cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	39 NX
Lung	39 NX

B-cells	34 NX
Kidney	80 NX
Colon	46 NX
Liver	18 NX

Basal glandular cells	250 NX
Prostate	250 NX

Basal keratinocytes	164 NX
Skin	164 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	80 NX
Heart muscle	80 NX

Cholangiocytes	97 NX
Liver	97 NX

Ciliated cells	31 NX
Lung	31 NX

Club cells	44 NX
Lung	44 NX

Collecting duct cells	227 NX
Kidney	227 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	281 NX
Placenta	281 NX

Distal tubular cells	139 NX
Kidney	139 NX

Ductal cells	747 NX
Pancreas	747 NX

Early spermatids	11 NX
Testis	11 NX

Endothelial cells	296 NX
Pancreas	766 NX
Prostate	754 NX
Placenta	564 NX
Heart muscle	309 NX
Liver	292 NX
Skin	287 NX
Testis	261 NX
Eye	243 NX
Lung	181 NX

Enterocytes	821 NX
Rectum	921 NX
Colon	834 NX
Small intestine	755 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	736 NX
Pancreas	736 NX

Extravillous trophoblasts	417 NX
Placenta	417 NX

Fibroblasts	225 NX
Placenta	320 NX
Prostate	232 NX
Skin	223 NX
Heart muscle	110 NX
Lung	62 NX

Glandular cells	313 NX
Prostate	313 NX

Granulocytes	61 NX
Colon	64 NX
Lung	58 NX

Hepatocytes	47 NX
Liver	47 NX

Hofbauer cells	152 NX
Placenta	152 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	82 NX
Colon	95 NX
Rectum	68 NX

Ito cells	324 NX
Liver	324 NX

Kupffer cells	87 NX
Liver	87 NX

Late spermatids	26 NX
Testis	25 NX

Leydig cells	139 NX
Testis	139 NX

Macrophages	212 NX
Kidney	315 NX
Skin	260 NX
Testis	241 NX
Prostate	182 NX
Pancreas	98 NX
Lung	76 NX

Melanocytes	233 NX
Skin	233 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	464 NX
Pancreas	464 NX

Mucus-secreting cells	189 NX
Small intestine	304 NX
Colon	245 NX
Rectum	103 NX

Muller glia cells	306 NX
Eye	306 NX

Pancreatic endocrine cells	918 NX
Pancreas	917 NX

Paneth cells	470 NX
Colon	1716 NX
Small intestine	470 NX
Rectum	335 NX

Peritubular cells	195 NX
Testis	195 NX

Proximal tubular cells	561 NX
Kidney	561 NX

Rod photoreceptor cells	11 NX
Eye	11 NX

Sertoli cells	213 NX
Testis	213 NX

Smooth muscle cells	270 NX
Pancreas	770 NX
Prostate	314 NX
Heart muscle	270 NX
Skin	212 NX

Spermatocytes	8 NX
Testis	8 NX

Spermatogonia	21 NX
Testis	21 NX

Suprabasal keratinocytes	147 NX
Skin	147 NX

Syncytiotrophoblasts	216 NX
Placenta	216 NX

T-cells	180 NX
Skin	185 NX
Colon	183 NX
Liver	181 NX
Kidney	151 NX
Lung	89 NX
Prostate	44 NX

Undifferentiated cells	146 NX
Colon	266 NX
Rectum	146 NX
Small intestine	118 NX

Urothelial cells	331 NX
Prostate	331 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.