Cell type atlas - MIA3 - The Human Protein Atlas

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MIA3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MIA3
Gene descriptionⁱ Full gene name according to HGNC.	MIA family member 3, ER export factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	45 NX
Lung	45 NX

B-cells	27 NX
Kidney	40 NX
Colon	33 NX
Liver	11 NX

Basal glandular cells	23 NX
Prostate	23 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	56 NX
Eye	55 NX

Cardiomyocytes	56 NX
Heart muscle	56 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	58 NX
Lung	58 NX

Collecting duct cells	5 NX
Kidney	5 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	21 NX
Pancreas	21 NX

Early spermatids	25 NX
Testis	25 NX

Endothelial cells	22 NX
Heart muscle	77 NX
Lung	58 NX
Eye	36 NX
Testis	26 NX
Prostate	22 NX
Placenta	20 NX
Skin	19 NX
Pancreas	18 NX
Liver	11 NX

Enterocytes	30 NX
Small intestine	36 NX
Rectum	34 NX
Colon	27 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	30 NX
Pancreas	30 NX

Extravillous trophoblasts	14 NX
Placenta	14 NX

Fibroblasts	25 NX
Heart muscle	87 NX
Lung	80 NX
Prostate	38 NX
Skin	26 NX
Placenta	22 NX

Glandular cells	40 NX
Prostate	40 NX

Granulocytes	16 NX
Lung	33 NX
Colon	0 NX

Hepatocytes	52 NX
Liver	52 NX

Hofbauer cells	19 NX
Placenta	18 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	58 NX
Colon	65 NX
Rectum	52 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	17 NX
Liver	17 NX

Late spermatids	18 NX
Testis	18 NX

Leydig cells	34 NX
Testis	34 NX

Macrophages	24 NX
Lung	53 NX
Prostate	31 NX
Testis	28 NX
Pancreas	19 NX
Kidney	19 NX
Skin	14 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	14 NX
Pancreas	14 NX

Mucus-secreting cells	83 NX
Colon	107 NX
Small intestine	97 NX
Rectum	60 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	27 NX
Pancreas	27 NX

Paneth cells	22 NX
Small intestine	28 NX
Rectum	22 NX
Colon	20 NX

Peritubular cells	46 NX
Testis	46 NX

Proximal tubular cells	22 NX
Kidney	22 NX

Rod photoreceptor cells	38 NX
Eye	38 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	26 NX
Heart muscle	91 NX
Prostate	26 NX
Skin	24 NX
Pancreas	21 NX

Spermatocytes	49 NX
Testis	49 NX

Spermatogonia	41 NX
Testis	41 NX

Suprabasal keratinocytes	14 NX
Skin	14 NX

Syncytiotrophoblasts	30 NX
Placenta	30 NX

T-cells	34 NX
Lung	78 NX
Prostate	39 NX
Colon	36 NX
Kidney	30 NX
Liver	27 NX
Skin	22 NX

Undifferentiated cells	23 NX
Colon	25 NX
Rectum	24 NX
Small intestine	18 NX

Urothelial cells	26 NX
Prostate	26 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.