Cell type atlas - CHD1 - The Human Protein Atlas

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CHD1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CHD1
Gene descriptionⁱ Full gene name according to HGNC.	Chromodomain helicase DNA binding protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	62 NX
Lung	62 NX

B-cells	41 NX
Colon	185 NX
Kidney	40 NX
Liver	35 NX

Basal glandular cells	98 NX
Prostate	98 NX

Basal keratinocytes	138 NX
Skin	138 NX

Bipolar cells	37 NX
Eye	37 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	62 NX
Lung	62 NX

Club cells	80 NX
Lung	80 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	41 NX
Eye	41 NX

Cytotrophoblasts	44 NX
Placenta	44 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	86 NX
Testis	86 NX

Endothelial cells	50 NX
Prostate	120 NX
Skin	101 NX
Lung	76 NX
Heart muscle	57 NX
Pancreas	50 NX
Eye	47 NX
Testis	44 NX
Placenta	33 NX
Liver	25 NX

Enterocytes	37 NX
Colon	63 NX
Rectum	51 NX
Small intestine	25 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	28 NX
Pancreas	28 NX

Extravillous trophoblasts	33 NX
Placenta	33 NX

Fibroblasts	76 NX
Prostate	256 NX
Lung	190 NX
Skin	129 NX
Heart muscle	28 NX
Placenta	27 NX

Glandular cells	64 NX
Prostate	64 NX

Granulocytes	86 NX
Lung	107 NX
Colon	64 NX

Hepatocytes	26 NX
Liver	26 NX

Hofbauer cells	31 NX
Placenta	31 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	31 NX
Colon	31 NX
Rectum	31 NX

Ito cells	36 NX
Liver	36 NX

Kupffer cells	72 NX
Liver	72 NX

Late spermatids	15 NX
Testis	15 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	68 NX
Lung	220 NX
Prostate	150 NX
Skin	105 NX
Kidney	64 NX
Testis	52 NX
Pancreas	37 NX

Melanocytes	64 NX
Skin	64 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	52 NX
Pancreas	52 NX

Mucus-secreting cells	29 NX
Colon	32 NX
Rectum	32 NX
Small intestine	20 NX

Muller glia cells	17 NX
Eye	17 NX

Pancreatic endocrine cells	30 NX
Pancreas	30 NX

Paneth cells	35 NX
Colon	69 NX
Small intestine	35 NX
Rectum	34 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	11 NX
Kidney	11 NX

Rod photoreceptor cells	50 NX
Eye	50 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	97 NX
Prostate	273 NX
Skin	247 NX
Heart muscle	35 NX
Pancreas	25 NX

Spermatocytes	52 NX
Testis	52 NX

Spermatogonia	53 NX
Testis	53 NX

Suprabasal keratinocytes	165 NX
Skin	165 NX

Syncytiotrophoblasts	76 NX
Placenta	76 NX

T-cells	54 NX
Colon	180 NX
Skin	129 NX
Lung	121 NX
Prostate	113 NX
Kidney	42 NX
Liver	38 NX

Undifferentiated cells	27 NX
Colon	46 NX
Rectum	27 NX
Small intestine	27 NX

Urothelial cells	58 NX
Prostate	58 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.