Cell type atlas - RPIA - The Human Protein Atlas

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RPIA

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPIA
Gene descriptionⁱ Full gene name according to HGNC.	Ribose 5-phosphate isomerase A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	10 NX
Lung	10 NX

B-cells	45 NX
Liver	49 NX
Colon	49 NX
Kidney	36 NX

Basal glandular cells	15 NX
Prostate	15 NX

Basal keratinocytes	33 NX
Skin	33 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	11 NX
Heart muscle	11 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	3 NX
Lung	3 NX

Club cells	3 NX
Lung	3 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	210 NX
Placenta	210 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	14 NX
Pancreas	14 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	27 NX
Placenta	63 NX
Pancreas	39 NX
Testis	37 NX
Skin	34 NX
Prostate	33 NX
Lung	26 NX
Eye	21 NX
Heart muscle	12 NX
Liver	7 NX

Enterocytes	15 NX
Rectum	23 NX
Small intestine	17 NX
Colon	13 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	30 NX
Pancreas	30 NX

Extravillous trophoblasts	70 NX
Placenta	70 NX

Fibroblasts	30 NX
Placenta	35 NX
Skin	29 NX
Prostate	25 NX
Heart muscle	14 NX
Lung	5 NX

Glandular cells	22 NX
Prostate	22 NX

Granulocytes	22 NX
Colon	37 NX
Lung	7 NX

Hepatocytes	6 NX
Liver	6 NX

Hofbauer cells	39 NX
Placenta	39 NX

Horizontal cells	13 NX
Eye	13 NX

Intestinal endocrine cells	18 NX
Colon	20 NX
Rectum	16 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	16 NX
Liver	16 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	23 NX
Prostate	36 NX
Kidney	35 NX
Skin	28 NX
Testis	20 NX
Pancreas	12 NX
Lung	10 NX

Melanocytes	39 NX
Skin	39 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	25 NX
Pancreas	25 NX

Mucus-secreting cells	25 NX
Rectum	31 NX
Small intestine	21 NX
Colon	19 NX

Muller glia cells	4 NX
Eye	4 NX

Pancreatic endocrine cells	21 NX
Pancreas	21 NX

Paneth cells	28 NX
Rectum	43 NX
Small intestine	28 NX
Colon	6 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	13 NX
Kidney	13 NX

Rod photoreceptor cells	5 NX
Eye	5 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	18 NX
Skin	27 NX
Pancreas	18 NX
Prostate	16 NX
Heart muscle	15 NX

Spermatocytes	25 NX
Testis	25 NX

Spermatogonia	33 NX
Testis	33 NX

Suprabasal keratinocytes	36 NX
Skin	36 NX

Syncytiotrophoblasts	189 NX
Placenta	189 NX

T-cells	37 NX
Colon	46 NX
Skin	43 NX
Kidney	43 NX
Liver	33 NX
Prostate	13 NX
Lung	12 NX

Undifferentiated cells	56 NX
Small intestine	68 NX
Colon	59 NX
Rectum	48 NX

Urothelial cells	36 NX
Prostate	36 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.