Cell type atlas - DAB2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DAB2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DAB2
Gene descriptionⁱ Full gene name according to HGNC.	DAB2, clathrin adaptor protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Hofbauer cells, Syncytiotrophoblasts, Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, TIME, U-138 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Hofbauer cells, Syncytiotrophoblasts, Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	26 NX
Kidney	103 NX
Liver	26 NX
Colon	9 NX

Basal glandular cells	1 NX
Prostate	1 NX

Basal keratinocytes	13 NX
Skin	13 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	50 NX
Heart muscle	50 NX

Cholangiocytes	61 NX
Liver	61 NX

Ciliated cells	9 NX
Lung	9 NX

Club cells	8 NX
Lung	8 NX

Collecting duct cells	91 NX
Kidney	91 NX

Cone photoreceptor cells	67 NX
Eye	67 NX

Cytotrophoblasts	112 NX
Placenta	112 NX

Distal tubular cells	168 NX
Kidney	168 NX

Ductal cells	58 NX
Pancreas	58 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	98 NX
Lung	146 NX
Prostate	139 NX
Eye	118 NX
Heart muscle	110 NX
Placenta	98 NX
Liver	97 NX
Skin	84 NX
Testis	69 NX
Pancreas	68 NX

Enterocytes	30 NX
Colon	33 NX
Small intestine	26 NX
Rectum	22 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	2 NX
Pancreas	2 NX

Extravillous trophoblasts	15 NX
Placenta	15 NX

Fibroblasts	121 NX
Skin	179 NX
Placenta	109 NX
Lung	97 NX
Heart muscle	77 NX
Prostate	73 NX

Glandular cells	7 NX
Prostate	7 NX

Granulocytes	24 NX
Lung	30 NX
Colon	18 NX

Hepatocytes	2 NX
Liver	2 NX

Hofbauer cells	1339 NX
Placenta	1339 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	9 NX
Rectum	19 NX
Colon	0 NX

Ito cells	215 NX
Liver	215 NX

Kupffer cells	132 NX
Liver	132 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	113 NX
Testis	113 NX

Macrophages	177 NX
Kidney	179 NX
Prostate	178 NX
Pancreas	176 NX
Lung	143 NX
Testis	128 NX
Skin	123 NX

Melanocytes	12 NX
Skin	12 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	7 NX
Pancreas	7 NX

Mucus-secreting cells	6 NX
Colon	7 NX
Rectum	6 NX
Small intestine	3 NX

Muller glia cells	72 NX
Eye	72 NX

Pancreatic endocrine cells	7 NX
Pancreas	7 NX

Paneth cells	13 NX
Colon	14 NX
Rectum	13 NX
Small intestine	0 NX

Peritubular cells	61 NX
Testis	61 NX

Proximal tubular cells	965 NX
Kidney	965 NX

Rod photoreceptor cells	2 NX
Eye	2 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	27 NX
Pancreas	135 NX
Skin	37 NX
Heart muscle	27 NX
Prostate	10 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	12 NX
Skin	12 NX

Syncytiotrophoblasts	1108 NX
Placenta	1108 NX

T-cells	11 NX
Kidney	83 NX
Lung	32 NX
Skin	11 NX
Prostate	9 NX
Liver	8 NX
Colon	2 NX

Undifferentiated cells	19 NX
Colon	25 NX
Rectum	21 NX
Small intestine	3 NX

Urothelial cells	1 NX
Prostate	1 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.