Cell type atlas - SAR1B - The Human Protein Atlas

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SAR1B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SAR1B
Gene descriptionⁱ Full gene name according to HGNC.	Secretion associated Ras related GTPase 1B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	29 NX
Lung	29 NX

B-cells	28 NX
Liver	68 NX
Kidney	31 NX
Colon	25 NX

Basal glandular cells	36 NX
Prostate	36 NX

Basal keratinocytes	33 NX
Skin	33 NX

Bipolar cells	29 NX
Eye	29 NX

Cardiomyocytes	70 NX
Heart muscle	70 NX

Cholangiocytes	64 NX
Liver	64 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	54 NX
Kidney	54 NX

Cone photoreceptor cells	39 NX
Eye	39 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	48 NX
Kidney	48 NX

Ductal cells	42 NX
Pancreas	42 NX

Early spermatids	296 NX
Testis	296 NX

Endothelial cells	30 NX
Heart muscle	45 NX
Eye	32 NX
Pancreas	32 NX
Prostate	31 NX
Skin	30 NX
Placenta	28 NX
Liver	25 NX
Testis	23 NX
Lung	23 NX

Enterocytes	96 NX
Small intestine	173 NX
Rectum	81 NX
Colon	42 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	73 NX
Pancreas	73 NX

Extravillous trophoblasts	34 NX
Placenta	34 NX

Fibroblasts	41 NX
Prostate	49 NX
Heart muscle	46 NX
Placenta	42 NX
Skin	39 NX
Lung	24 NX

Glandular cells	75 NX
Prostate	75 NX

Granulocytes	26 NX
Lung	33 NX
Colon	18 NX

Hepatocytes	238 NX
Liver	238 NX

Hofbauer cells	47 NX
Placenta	47 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	27 NX
Rectum	33 NX
Colon	20 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	55 NX
Liver	55 NX

Late spermatids	51 NX
Testis	51 NX

Leydig cells	34 NX
Testis	34 NX

Macrophages	46 NX
Pancreas	59 NX
Prostate	58 NX
Kidney	54 NX
Skin	46 NX
Testis	38 NX
Lung	31 NX

Melanocytes	61 NX
Skin	61 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	31 NX
Pancreas	31 NX

Mucus-secreting cells	50 NX
Small intestine	59 NX
Colon	50 NX
Rectum	34 NX

Muller glia cells	41 NX
Eye	41 NX

Pancreatic endocrine cells	60 NX
Pancreas	60 NX

Paneth cells	29 NX
Rectum	45 NX
Colon	29 NX
Small intestine	25 NX

Peritubular cells	42 NX
Testis	42 NX

Proximal tubular cells	103 NX
Kidney	103 NX

Rod photoreceptor cells	37 NX
Eye	37 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	43 NX
Pancreas	71 NX
Prostate	51 NX
Heart muscle	43 NX
Skin	38 NX

Spermatocytes	103 NX
Testis	103 NX

Spermatogonia	38 NX
Testis	38 NX

Suprabasal keratinocytes	45 NX
Skin	45 NX

Syncytiotrophoblasts	96 NX
Placenta	96 NX

T-cells	37 NX
Colon	57 NX
Prostate	52 NX
Skin	48 NX
Kidney	40 NX
Liver	36 NX
Lung	32 NX

Undifferentiated cells	43 NX
Small intestine	46 NX
Colon	43 NX
Rectum	29 NX

Urothelial cells	77 NX
Prostate	77 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.