Cell type atlas - USP12 - The Human Protein Atlas

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USP12

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP12
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 12
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	25 NX
Lung	25 NX

B-cells	15 NX
Colon	48 NX
Kidney	18 NX
Liver	6 NX

Basal glandular cells	23 NX
Prostate	23 NX

Basal keratinocytes	82 NX
Skin	82 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	23 NX
Heart muscle	23 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	16 NX
Lung	16 NX

Club cells	10 NX
Lung	10 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	12 NX
Placenta	12 NX

Distal tubular cells	25 NX
Kidney	25 NX

Ductal cells	12 NX
Pancreas	12 NX

Early spermatids	17 NX
Testis	17 NX

Endothelial cells	32 NX
Prostate	99 NX
Skin	63 NX
Eye	42 NX
Heart muscle	33 NX
Lung	23 NX
Placenta	16 NX
Testis	13 NX
Pancreas	11 NX
Liver	11 NX

Enterocytes	33 NX
Rectum	48 NX
Colon	35 NX
Small intestine	29 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	14 NX
Pancreas	14 NX

Extravillous trophoblasts	6 NX
Placenta	6 NX

Fibroblasts	31 NX
Prostate	63 NX
Skin	54 NX
Heart muscle	39 NX
Lung	22 NX
Placenta	9 NX

Glandular cells	29 NX
Prostate	29 NX

Granulocytes	13 NX
Lung	16 NX
Colon	9 NX

Hepatocytes	22 NX
Liver	22 NX

Hofbauer cells	13 NX
Placenta	13 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	20 NX
Colon	24 NX
Rectum	16 NX

Ito cells	17 NX
Liver	17 NX

Kupffer cells	16 NX
Liver	16 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	7 NX
Testis	7 NX

Macrophages	23 NX
Skin	90 NX
Prostate	79 NX
Lung	23 NX
Pancreas	19 NX
Testis	16 NX
Kidney	12 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	44 NX
Pancreas	44 NX

Mucus-secreting cells	24 NX
Small intestine	27 NX
Colon	24 NX
Rectum	24 NX

Muller glia cells	11 NX
Eye	11 NX

Pancreatic endocrine cells	20 NX
Pancreas	20 NX

Paneth cells	26 NX
Colon	63 NX
Rectum	26 NX
Small intestine	11 NX

Peritubular cells	6 NX
Testis	6 NX

Proximal tubular cells	16 NX
Kidney	16 NX

Rod photoreceptor cells	30 NX
Eye	30 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	45 NX
Prostate	82 NX
Skin	72 NX
Heart muscle	31 NX
Pancreas	10 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	9 NX
Testis	9 NX

Suprabasal keratinocytes	69 NX
Skin	69 NX

Syncytiotrophoblasts	9 NX
Placenta	9 NX

T-cells	14 NX
Skin	36 NX
Prostate	31 NX
Colon	29 NX
Liver	13 NX
Kidney	11 NX
Lung	9 NX

Undifferentiated cells	20 NX
Rectum	24 NX
Colon	20 NX
Small intestine	19 NX

Urothelial cells	30 NX
Prostate	30 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.