Cell type atlas - SLC25A4 - The Human Protein Atlas

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SLC25A4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A4
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes FDA approved drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	80 NX
Lung	80 NX

Alveolar cells type 2	55 NX
Lung	55 NX

B-cells	34 NX
Liver	56 NX
Colon	40 NX
Kidney	27 NX

Basal glandular cells	126 NX
Prostate	126 NX

Basal keratinocytes	39 NX
Skin	39 NX

Bipolar cells	174 NX
Eye	174 NX

Cardiomyocytes	4236 NX
Heart muscle	4236 NX

Cholangiocytes	140 NX
Liver	140 NX

Ciliated cells	112 NX
Lung	112 NX

Club cells	42 NX
Lung	42 NX

Collecting duct cells	68 NX
Kidney	68 NX

Cone photoreceptor cells	98 NX
Eye	98 NX

Cytotrophoblasts	60 NX
Placenta	60 NX

Distal tubular cells	837 NX
Kidney	837 NX

Ductal cells	68 NX
Pancreas	68 NX

Early spermatids	16 NX
Testis	16 NX

Endothelial cells	26 NX
Heart muscle	515 NX
Eye	184 NX
Skin	32 NX
Prostate	29 NX
Placenta	26 NX
Pancreas	22 NX
Lung	20 NX
Liver	16 NX
Testis	15 NX

Enterocytes	41 NX
Small intestine	95 NX
Rectum	49 NX
Colon	38 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	65 NX
Pancreas	65 NX

Extravillous trophoblasts	48 NX
Placenta	48 NX

Fibroblasts	25 NX
Heart muscle	927 NX
Lung	34 NX
Prostate	30 NX
Skin	23 NX
Placenta	15 NX

Glandular cells	55 NX
Prostate	55 NX

Granulocytes	12 NX
Lung	14 NX
Colon	9 NX

Hepatocytes	84 NX
Liver	84 NX

Hofbauer cells	50 NX
Placenta	50 NX

Horizontal cells	151 NX
Eye	151 NX

Intestinal endocrine cells	52 NX
Colon	61 NX
Rectum	42 NX

Ito cells	25 NX
Liver	25 NX

Kupffer cells	8 NX
Liver	8 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	43 NX
Testis	43 NX

Macrophages	8 NX
Testis	12 NX
Prostate	12 NX
Kidney	10 NX
Skin	9 NX
Lung	4 NX
Pancreas	2 NX

Melanocytes	181 NX
Skin	181 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	15 NX
Pancreas	15 NX

Mucus-secreting cells	36 NX
Small intestine	39 NX
Rectum	36 NX
Colon	35 NX

Muller glia cells	473 NX
Eye	473 NX

Pancreatic endocrine cells	51 NX
Pancreas	51 NX

Paneth cells	25 NX
Rectum	39 NX
Small intestine	25 NX
Colon	14 NX

Peritubular cells	106 NX
Testis	106 NX

Proximal tubular cells	141 NX
Kidney	141 NX

Rod photoreceptor cells	178 NX
Eye	178 NX

Sertoli cells	104 NX
Testis	104 NX

Smooth muscle cells	195 NX
Heart muscle	580 NX
Prostate	299 NX
Skin	119 NX
Pancreas	32 NX

Spermatocytes	24 NX
Testis	24 NX

Spermatogonia	35 NX
Testis	35 NX

Suprabasal keratinocytes	16 NX
Skin	16 NX

Syncytiotrophoblasts	34 NX
Placenta	34 NX

T-cells	11 NX
Prostate	65 NX
Skin	47 NX
Kidney	26 NX
Colon	24 NX
Lung	6 NX
Liver	5 NX

Undifferentiated cells	49 NX
Rectum	59 NX
Colon	49 NX
Small intestine	48 NX

Urothelial cells	47 NX
Prostate	47 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.