Cell type atlas - NDUFC2 - The Human Protein Atlas

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NDUFC2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFC2
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit C2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	155 NX
Lung	155 NX

Alveolar cells type 2	160 NX
Lung	160 NX

B-cells	100 NX
Liver	177 NX
Kidney	134 NX
Colon	67 NX

Basal glandular cells	139 NX
Prostate	139 NX

Basal keratinocytes	85 NX
Skin	85 NX

Bipolar cells	134 NX
Eye	134 NX

Cardiomyocytes	214 NX
Heart muscle	214 NX

Cholangiocytes	247 NX
Liver	247 NX

Ciliated cells	202 NX
Lung	202 NX

Club cells	145 NX
Lung	145 NX

Collecting duct cells	372 NX
Kidney	372 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	348 NX
Placenta	347 NX

Distal tubular cells	259 NX
Kidney	259 NX

Ductal cells	335 NX
Pancreas	335 NX

Early spermatids	231 NX
Testis	231 NX

Endothelial cells	159 NX
Placenta	340 NX
Pancreas	319 NX
Testis	191 NX
Prostate	166 NX
Liver	164 NX
Heart muscle	135 NX
Skin	130 NX
Lung	108 NX
Eye	98 NX

Enterocytes	178 NX
Small intestine	387 NX
Rectum	243 NX
Colon	158 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	375 NX
Pancreas	375 NX

Extravillous trophoblasts	318 NX
Placenta	318 NX

Fibroblasts	154 NX
Placenta	289 NX
Heart muscle	155 NX
Prostate	154 NX
Skin	133 NX
Lung	129 NX

Glandular cells	190 NX
Prostate	190 NX

Granulocytes	148 NX
Lung	167 NX
Colon	129 NX

Hepatocytes	738 NX
Liver	738 NX

Hofbauer cells	305 NX
Placenta	305 NX

Horizontal cells	86 NX
Eye	86 NX

Intestinal endocrine cells	161 NX
Rectum	166 NX
Colon	156 NX

Ito cells	184 NX
Liver	184 NX

Kupffer cells	180 NX
Liver	180 NX

Late spermatids	53 NX
Testis	53 NX

Leydig cells	200 NX
Testis	200 NX

Macrophages	133 NX
Pancreas	330 NX
Kidney	227 NX
Lung	151 NX
Testis	139 NX
Prostate	116 NX
Skin	112 NX

Melanocytes	233 NX
Skin	233 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	194 NX
Pancreas	194 NX

Mucus-secreting cells	274 NX
Colon	293 NX
Small intestine	290 NX
Rectum	272 NX

Muller glia cells	214 NX
Eye	214 NX

Pancreatic endocrine cells	379 NX
Pancreas	379 NX

Paneth cells	302 NX
Small intestine	463 NX
Rectum	302 NX
Colon	138 NX

Peritubular cells	190 NX
Testis	190 NX

Proximal tubular cells	355 NX
Kidney	355 NX

Rod photoreceptor cells	92 NX
Eye	92 NX

Sertoli cells	233 NX
Testis	233 NX

Smooth muscle cells	164 NX
Pancreas	586 NX
Heart muscle	175 NX
Prostate	152 NX
Skin	151 NX

Spermatocytes	381 NX
Testis	381 NX

Spermatogonia	170 NX
Testis	170 NX

Suprabasal keratinocytes	100 NX
Skin	100 NX

Syncytiotrophoblasts	324 NX
Placenta	324 NX

T-cells	113 NX
Kidney	185 NX
Lung	152 NX
Liver	115 NX
Prostate	113 NX
Skin	105 NX
Colon	90 NX

Undifferentiated cells	343 NX
Small intestine	385 NX
Rectum	333 NX
Colon	269 NX

Urothelial cells	186 NX
Prostate	186 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.