Cell type atlas - CRIM1 - The Human Protein Atlas

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CRIM1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CRIM1
Gene descriptionⁱ Full gene name according to HGNC.	Cysteine rich transmembrane BMP regulator 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ito cells, Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ, fHDF/TERT166, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ito cells, Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	47 NX
Lung	47 NX

B-cells	5 NX
Kidney	9 NX
Liver	5 NX
Colon	2 NX

Basal glandular cells	35 NX
Prostate	35 NX

Basal keratinocytes	59 NX
Skin	59 NX

Bipolar cells	7 NX
Eye	7 NX

Cardiomyocytes	36 NX
Heart muscle	36 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	35 NX
Lung	35 NX

Collecting duct cells	126 NX
Kidney	126 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	107 NX
Placenta	107 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	29 NX
Pancreas	29 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	119 NX
Liver	499 NX
Heart muscle	182 NX
Skin	143 NX
Lung	137 NX
Testis	119 NX
Pancreas	107 NX
Prostate	75 NX
Placenta	74 NX
Eye	65 NX

Enterocytes	19 NX
Rectum	63 NX
Colon	21 NX
Small intestine	10 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	2 NX
Pancreas	2 NX

Extravillous trophoblasts	34 NX
Placenta	34 NX

Fibroblasts	49 NX
Lung	87 NX
Placenta	56 NX
Prostate	49 NX
Heart muscle	30 NX
Skin	27 NX

Glandular cells	52 NX
Prostate	52 NX

Granulocytes	1 NX
Lung	2 NX
Colon	0 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	22 NX
Placenta	22 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	31 NX
Colon	31 NX
Rectum	31 NX

Ito cells	170 NX
Liver	170 NX

Kupffer cells	7 NX
Liver	7 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	11 NX
Skin	23 NX
Lung	13 NX
Kidney	11 NX
Testis	10 NX
Prostate	8 NX
Pancreas	5 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	11 NX
Pancreas	11 NX

Mucus-secreting cells	41 NX
Rectum	50 NX
Small intestine	32 NX
Colon	22 NX

Muller glia cells	16 NX
Eye	16 NX

Pancreatic endocrine cells	17 NX
Pancreas	17 NX

Paneth cells	32 NX
Rectum	34 NX
Colon	32 NX
Small intestine	18 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	37 NX
Kidney	37 NX

Rod photoreceptor cells	38 NX
Eye	38 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	115 NX
Skin	154 NX
Heart muscle	143 NX
Prostate	52 NX
Pancreas	51 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	9 NX
Testis	9 NX

Suprabasal keratinocytes	26 NX
Skin	26 NX

Syncytiotrophoblasts	145 NX
Placenta	145 NX

T-cells	14 NX
Skin	39 NX
Colon	16 NX
Liver	14 NX
Lung	13 NX
Kidney	6 NX
Prostate	4 NX

Undifferentiated cells	32 NX
Rectum	44 NX
Colon	21 NX
Small intestine	17 NX

Urothelial cells	41 NX
Prostate	41 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.