Cell type atlas - HNMT - The Human Protein Atlas

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HNMT

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HNMT
Gene descriptionⁱ Full gene name according to HGNC.	Histamine N-methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (classical monocyte, intermediate monocyte, myeloid DC, non-classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Hep G2, HSkMC, RT4, SuSa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	39 NX
Lung	39 NX

B-cells	14 NX
Colon	16 NX
Kidney	13 NX
Liver	10 NX

Basal glandular cells	77 NX
Prostate	77 NX

Basal keratinocytes	32 NX
Skin	32 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	2 NX
Heart muscle	2 NX

Cholangiocytes	140 NX
Liver	140 NX

Ciliated cells	52 NX
Lung	52 NX

Club cells	86 NX
Lung	86 NX

Collecting duct cells	58 NX
Kidney	58 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	45 NX
Placenta	45 NX

Distal tubular cells	105 NX
Kidney	105 NX

Ductal cells	85 NX
Pancreas	85 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	5 NX
Eye	31 NX
Lung	15 NX
Skin	9 NX
Liver	9 NX
Placenta	8 NX
Heart muscle	4 NX
Prostate	3 NX
Testis	2 NX
Pancreas	0 NX

Enterocytes	45 NX
Colon	52 NX
Rectum	45 NX
Small intestine	28 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	42 NX
Pancreas	42 NX

Extravillous trophoblasts	70 NX
Placenta	70 NX

Fibroblasts	46 NX
Skin	68 NX
Heart muscle	48 NX
Placenta	40 NX
Prostate	23 NX
Lung	9 NX

Glandular cells	48 NX
Prostate	48 NX

Granulocytes	0 NX
Colon	0 NX
Lung	0 NX

Hepatocytes	146 NX
Liver	146 NX

Hofbauer cells	259 NX
Placenta	259 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	16 NX
Rectum	28 NX
Colon	3 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	235 NX
Liver	235 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	122 NX
Testis	122 NX

Macrophages	155 NX
Pancreas	208 NX
Kidney	204 NX
Testis	174 NX
Skin	119 NX
Lung	98 NX
Prostate	80 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	69 NX
Pancreas	69 NX

Mucus-secreting cells	66 NX
Rectum	76 NX
Small intestine	56 NX
Colon	49 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	58 NX
Pancreas	58 NX

Paneth cells	100 NX
Small intestine	133 NX
Rectum	100 NX
Colon	63 NX

Peritubular cells	99 NX
Testis	99 NX

Proximal tubular cells	190 NX
Kidney	190 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	53 NX
Skin	75 NX
Heart muscle	65 NX
Pancreas	53 NX
Prostate	42 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	23 NX
Skin	23 NX

Syncytiotrophoblasts	32 NX
Placenta	32 NX

T-cells	5 NX
Kidney	13 NX
Lung	10 NX
Skin	8 NX
Liver	4 NX
Colon	1 NX
Prostate	0 NX

Undifferentiated cells	76 NX
Rectum	77 NX
Small intestine	76 NX
Colon	70 NX

Urothelial cells	103 NX
Prostate	103 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.