Cell type atlas - ITGB1 - The Human Protein Atlas

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ITGB1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITGB1
Gene descriptionⁱ Full gene name according to HGNC.	Integrin subunit beta 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers FDA approved drug targets Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ductal cells, Pancreatic endocrine cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (hTERT-RPE1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ductal cells, Pancreatic endocrine cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	319 NX
Lung	319 NX

Alveolar cells type 2	129 NX
Lung	129 NX

B-cells	76 NX
Kidney	156 NX
Liver	62 NX
Colon	57 NX

Basal glandular cells	296 NX
Prostate	296 NX

Basal keratinocytes	486 NX
Skin	486 NX

Bipolar cells	33 NX
Eye	33 NX

Cardiomyocytes	175 NX
Heart muscle	175 NX

Cholangiocytes	242 NX
Liver	242 NX

Ciliated cells	165 NX
Lung	165 NX

Club cells	253 NX
Lung	253 NX

Collecting duct cells	215 NX
Kidney	215 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	157 NX
Placenta	157 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	1163 NX
Pancreas	1163 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	315 NX
Pancreas	534 NX
Lung	510 NX
Eye	452 NX
Placenta	394 NX
Prostate	316 NX
Liver	315 NX
Skin	243 NX
Testis	216 NX
Heart muscle	180 NX

Enterocytes	84 NX
Rectum	201 NX
Colon	117 NX
Small intestine	70 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	356 NX
Pancreas	356 NX

Extravillous trophoblasts	460 NX
Placenta	460 NX

Fibroblasts	265 NX
Lung	558 NX
Prostate	339 NX
Skin	325 NX
Heart muscle	216 NX
Placenta	211 NX

Glandular cells	177 NX
Prostate	177 NX

Granulocytes	87 NX
Colon	92 NX
Lung	81 NX

Hepatocytes	221 NX
Liver	221 NX

Hofbauer cells	161 NX
Placenta	161 NX

Horizontal cells	37 NX
Eye	37 NX

Intestinal endocrine cells	186 NX
Colon	207 NX
Rectum	164 NX

Ito cells	388 NX
Liver	388 NX

Kupffer cells	153 NX
Liver	153 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	236 NX
Testis	236 NX

Macrophages	174 NX
Lung	245 NX
Pancreas	229 NX
Skin	173 NX
Prostate	159 NX
Kidney	155 NX
Testis	142 NX

Melanocytes	326 NX
Skin	326 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	83 NX
Pancreas	83 NX

Mucus-secreting cells	81 NX
Rectum	102 NX
Colon	81 NX
Small intestine	79 NX

Muller glia cells	77 NX
Eye	77 NX

Pancreatic endocrine cells	917 NX
Pancreas	917 NX

Paneth cells	113 NX
Small intestine	126 NX
Rectum	113 NX
Colon	109 NX

Peritubular cells	566 NX
Testis	566 NX

Proximal tubular cells	64 NX
Kidney	64 NX

Rod photoreceptor cells	45 NX
Eye	45 NX

Sertoli cells	627 NX
Testis	627 NX

Smooth muscle cells	497 NX
Pancreas	1110 NX
Prostate	579 NX
Heart muscle	473 NX
Skin	457 NX

Spermatocytes	10 NX
Testis	10 NX

Spermatogonia	64 NX
Testis	64 NX

Suprabasal keratinocytes	149 NX
Skin	149 NX

Syncytiotrophoblasts	184 NX
Placenta	184 NX

T-cells	107 NX
Skin	345 NX
Kidney	275 NX
Lung	211 NX
Liver	104 NX
Prostate	61 NX
Colon	56 NX

Undifferentiated cells	99 NX
Colon	142 NX
Rectum	110 NX
Small intestine	81 NX

Urothelial cells	257 NX
Prostate	257 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.