Cell type atlas - PPP4C - The Human Protein Atlas

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PPP4C

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPP4C
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase 4 catalytic subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	33 NX
Lung	33 NX

B-cells	82 NX
Colon	108 NX
Liver	87 NX
Kidney	49 NX

Basal glandular cells	97 NX
Prostate	97 NX

Basal keratinocytes	131 NX
Skin	131 NX

Bipolar cells	20 NX
Eye	20 NX

Cardiomyocytes	9 NX
Heart muscle	9 NX

Cholangiocytes	89 NX
Liver	89 NX

Ciliated cells	55 NX
Lung	55 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	73 NX
Kidney	73 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	269 NX
Placenta	269 NX

Distal tubular cells	134 NX
Kidney	134 NX

Ductal cells	208 NX
Pancreas	208 NX

Early spermatids	128 NX
Testis	128 NX

Endothelial cells	84 NX
Pancreas	176 NX
Placenta	171 NX
Prostate	129 NX
Skin	92 NX
Testis	84 NX
Liver	56 NX
Eye	43 NX
Lung	20 NX
Heart muscle	19 NX

Enterocytes	174 NX
Colon	212 NX
Small intestine	158 NX
Rectum	146 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	170 NX
Pancreas	170 NX

Extravillous trophoblasts	278 NX
Placenta	278 NX

Fibroblasts	71 NX
Placenta	164 NX
Prostate	71 NX
Skin	68 NX
Lung	26 NX
Heart muscle	12 NX

Glandular cells	112 NX
Prostate	112 NX

Granulocytes	69 NX
Colon	101 NX
Lung	37 NX

Hepatocytes	86 NX
Liver	86 NX

Hofbauer cells	210 NX
Placenta	210 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	121 NX
Colon	143 NX
Rectum	98 NX

Ito cells	59 NX
Liver	59 NX

Kupffer cells	91 NX
Liver	91 NX

Late spermatids	98 NX
Testis	98 NX

Leydig cells	58 NX
Testis	58 NX

Macrophages	124 NX
Pancreas	267 NX
Kidney	203 NX
Prostate	137 NX
Testis	123 NX
Skin	119 NX
Lung	64 NX

Melanocytes	76 NX
Skin	76 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	253 NX
Pancreas	253 NX

Mucus-secreting cells	114 NX
Colon	189 NX
Small intestine	138 NX
Rectum	100 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	255 NX
Pancreas	255 NX

Paneth cells	168 NX
Colon	311 NX
Small intestine	168 NX
Rectum	115 NX

Peritubular cells	49 NX
Testis	49 NX

Proximal tubular cells	156 NX
Kidney	156 NX

Rod photoreceptor cells	26 NX
Eye	26 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	65 NX
Pancreas	230 NX
Skin	70 NX
Prostate	58 NX
Heart muscle	13 NX

Spermatocytes	232 NX
Testis	232 NX

Spermatogonia	142 NX
Testis	142 NX

Suprabasal keratinocytes	151 NX
Skin	151 NX

Syncytiotrophoblasts	352 NX
Placenta	352 NX

T-cells	111 NX
Kidney	132 NX
Liver	126 NX
Colon	111 NX
Skin	103 NX
Prostate	61 NX
Lung	49 NX

Undifferentiated cells	129 NX
Colon	214 NX
Small intestine	140 NX
Rectum	107 NX

Urothelial cells	193 NX
Prostate	193 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.