Cell type atlas - AASDHPPT - The Human Protein Atlas

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AASDHPPT

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AASDHPPT
Gene descriptionⁱ Full gene name according to HGNC.	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	25 NX
Lung	25 NX

B-cells	34 NX
Kidney	45 NX
Liver	29 NX
Colon	24 NX

Basal glandular cells	25 NX
Prostate	25 NX

Basal keratinocytes	18 NX
Skin	18 NX

Bipolar cells	33 NX
Eye	33 NX

Cardiomyocytes	21 NX
Heart muscle	21 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	27 NX
Lung	27 NX

Collecting duct cells	17 NX
Kidney	17 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	70 NX
Placenta	70 NX

Distal tubular cells	33 NX
Kidney	33 NX

Ductal cells	28 NX
Pancreas	28 NX

Early spermatids	308 NX
Testis	308 NX

Endothelial cells	20 NX
Testis	26 NX
Liver	25 NX
Placenta	24 NX
Eye	20 NX
Lung	20 NX
Pancreas	18 NX
Prostate	17 NX
Heart muscle	16 NX
Skin	16 NX

Enterocytes	8 NX
Small intestine	10 NX
Rectum	8 NX
Colon	5 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	57 NX
Placenta	57 NX

Fibroblasts	31 NX
Lung	59 NX
Placenta	49 NX
Prostate	31 NX
Heart muscle	15 NX
Skin	14 NX

Glandular cells	18 NX
Prostate	18 NX

Granulocytes	29 NX
Lung	30 NX
Colon	28 NX

Hepatocytes	33 NX
Liver	33 NX

Hofbauer cells	34 NX
Placenta	34 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	18 NX
Rectum	19 NX
Colon	17 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	18 NX
Liver	18 NX

Late spermatids	42 NX
Testis	42 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	23 NX
Kidney	37 NX
Lung	27 NX
Prostate	24 NX
Testis	23 NX
Skin	21 NX
Pancreas	16 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	25 NX
Pancreas	25 NX

Mucus-secreting cells	12 NX
Rectum	14 NX
Colon	10 NX
Small intestine	9 NX

Muller glia cells	63 NX
Eye	63 NX

Pancreatic endocrine cells	20 NX
Pancreas	20 NX

Paneth cells	9 NX
Rectum	12 NX
Colon	9 NX
Small intestine	7 NX

Peritubular cells	25 NX
Testis	25 NX

Proximal tubular cells	59 NX
Kidney	59 NX

Rod photoreceptor cells	16 NX
Eye	16 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	18 NX
Pancreas	33 NX
Prostate	23 NX
Skin	17 NX
Heart muscle	9 NX

Spermatocytes	43 NX
Testis	43 NX

Spermatogonia	39 NX
Testis	39 NX

Suprabasal keratinocytes	21 NX
Skin	21 NX

Syncytiotrophoblasts	33 NX
Placenta	33 NX

T-cells	30 NX
Kidney	40 NX
Lung	32 NX
Colon	32 NX
Liver	30 NX
Prostate	13 NX
Skin	13 NX

Undifferentiated cells	14 NX
Small intestine	15 NX
Rectum	14 NX
Colon	8 NX

Urothelial cells	16 NX
Prostate	16 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.