Cell type atlas - PAK1 - The Human Protein Atlas

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PAK1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PAK1
Gene descriptionⁱ Full gene name according to HGNC.	P21 (RAC1) activated kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (granulocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, eosinophil, myeloid DC, non-classical monocyte, classical monocyte, intermediate monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (granulocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	3 NX
Lung	3 NX

Alveolar cells type 2	22 NX
Lung	22 NX

B-cells	16 NX
Colon	37 NX
Kidney	18 NX
Liver	7 NX

Basal glandular cells	28 NX
Prostate	28 NX

Basal keratinocytes	11 NX
Skin	11 NX

Bipolar cells	48 NX
Eye	48 NX

Cardiomyocytes	3 NX
Heart muscle	3 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	42 NX
Lung	42 NX

Club cells	33 NX
Lung	33 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	38 NX
Kidney	38 NX

Ductal cells	26 NX
Pancreas	26 NX

Early spermatids	32 NX
Testis	31 NX

Endothelial cells	3 NX
Lung	9 NX
Eye	8 NX
Testis	3 NX
Skin	3 NX
Heart muscle	3 NX
Prostate	3 NX
Placenta	2 NX
Pancreas	0 NX
Liver	0 NX

Enterocytes	46 NX
Rectum	74 NX
Colon	60 NX
Small intestine	41 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	49 NX
Pancreas	49 NX

Extravillous trophoblasts	46 NX
Placenta	46 NX

Fibroblasts	13 NX
Lung	47 NX
Heart muscle	33 NX
Prostate	31 NX
Skin	12 NX
Placenta	9 NX

Glandular cells	26 NX
Prostate	26 NX

Granulocytes	126 NX
Lung	170 NX
Colon	83 NX

Hepatocytes	11 NX
Liver	11 NX

Hofbauer cells	45 NX
Placenta	45 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	36 NX
Colon	37 NX
Rectum	35 NX

Ito cells	3 NX
Liver	3 NX

Kupffer cells	44 NX
Liver	44 NX

Late spermatids	20 NX
Testis	20 NX

Leydig cells	13 NX
Testis	13 NX

Macrophages	71 NX
Skin	107 NX
Testis	85 NX
Kidney	75 NX
Lung	69 NX
Prostate	62 NX
Pancreas	35 NX

Melanocytes	29 NX
Skin	29 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	95 NX
Pancreas	95 NX

Mucus-secreting cells	47 NX
Rectum	53 NX
Small intestine	43 NX
Colon	42 NX

Muller glia cells	14 NX
Eye	14 NX

Pancreatic endocrine cells	42 NX
Pancreas	42 NX

Paneth cells	55 NX
Small intestine	56 NX
Rectum	55 NX
Colon	46 NX

Peritubular cells	12 NX
Testis	12 NX

Proximal tubular cells	29 NX
Kidney	29 NX

Rod photoreceptor cells	7 NX
Eye	7 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	18 NX
Pancreas	21 NX
Heart muscle	18 NX
Skin	12 NX
Prostate	10 NX

Spermatocytes	26 NX
Testis	26 NX

Spermatogonia	42 NX
Testis	42 NX

Suprabasal keratinocytes	9 NX
Skin	9 NX

Syncytiotrophoblasts	79 NX
Placenta	79 NX

T-cells	12 NX
Prostate	39 NX
Lung	35 NX
Skin	18 NX
Kidney	14 NX
Colon	12 NX
Liver	3 NX

Undifferentiated cells	47 NX
Small intestine	57 NX
Rectum	46 NX
Colon	33 NX

Urothelial cells	27 NX
Prostate	27 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.