Cell type atlas - SERPING1 - The Human Protein Atlas

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SERPING1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SERPING1
Gene descriptionⁱ Full gene name according to HGNC.	Serpin family G member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Candidate cardiovascular disease genes Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes, Cholangiocytes, Leydig cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, plasmacytoid DC, intermediate monocyte, classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Group enriched (ASC diff, ASC TERT1, HSkMC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes, Cholangiocytes, Leydig cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	110 NX
Lung	110 NX

Alveolar cells type 2	95 NX
Lung	95 NX

B-cells	7 NX
Liver	39 NX
Kidney	0 NX
Colon	0 NX

Basal glandular cells	53 NX
Prostate	53 NX

Basal keratinocytes	67 NX
Skin	67 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	20 NX
Heart muscle	20 NX

Cholangiocytes	749 NX
Liver	749 NX

Ciliated cells	35 NX
Lung	35 NX

Club cells	102 NX
Lung	102 NX

Collecting duct cells	150 NX
Kidney	150 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	17 NX
Placenta	17 NX

Distal tubular cells	37 NX
Kidney	37 NX

Ductal cells	333 NX
Pancreas	333 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	154 NX
Lung	196 NX
Heart muscle	187 NX
Liver	178 NX
Testis	154 NX
Skin	146 NX
Eye	141 NX
Placenta	130 NX
Prostate	125 NX
Pancreas	18 NX

Enterocytes	0 NX
Rectum	0 NX
Colon	0 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	39 NX
Pancreas	39 NX

Extravillous trophoblasts	87 NX
Placenta	87 NX

Fibroblasts	278 NX
Heart muscle	824 NX
Prostate	787 NX
Skin	607 NX
Lung	255 NX
Placenta	196 NX

Glandular cells	25 NX
Prostate	25 NX

Granulocytes	7 NX
Lung	14 NX
Colon	0 NX

Hepatocytes	2308 NX
Liver	2308 NX

Hofbauer cells	40 NX
Placenta	40 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	0 NX
Colon	0 NX
Rectum	0 NX

Ito cells	231 NX
Liver	231 NX

Kupffer cells	86 NX
Liver	86 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	681 NX
Testis	681 NX

Macrophages	41 NX
Lung	233 NX
Skin	75 NX
Testis	41 NX
Kidney	31 NX
Prostate	22 NX
Pancreas	2 NX

Melanocytes	86 NX
Skin	86 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	13 NX
Pancreas	13 NX

Mucus-secreting cells	0 NX
Rectum	0 NX
Small intestine	0 NX
Colon	0 NX

Muller glia cells	53 NX
Eye	53 NX

Pancreatic endocrine cells	58 NX
Pancreas	58 NX

Paneth cells	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Peritubular cells	215 NX
Testis	215 NX

Proximal tubular cells	42 NX
Kidney	42 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	265 NX
Testis	265 NX

Smooth muscle cells	283 NX
Prostate	466 NX
Heart muscle	283 NX
Skin	234 NX
Pancreas	57 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	3 NX
Testis	3 NX

Suprabasal keratinocytes	52 NX
Skin	52 NX

Syncytiotrophoblasts	21 NX
Placenta	21 NX

T-cells	40 NX
Lung	63 NX
Skin	54 NX
Liver	41 NX
Kidney	8 NX
Prostate	4 NX
Colon	0 NX

Undifferentiated cells	0 NX
Rectum	0 NX
Small intestine	0 NX
Colon	0 NX

Urothelial cells	31 NX
Prostate	31 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.