Cell type atlas - ADM - The Human Protein Atlas

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ADM

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADM
Gene descriptionⁱ Full gene name according to HGNC.	Adrenomedullin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Basal glandular cells, Extravillous trophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff, fHDF/TERT166, HSkMC, U-138 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Basal glandular cells, Extravillous trophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	20 NX
Lung	20 NX

B-cells	28 NX
Liver	38 NX
Colon	28 NX
Kidney	9 NX

Basal glandular cells	625 NX
Prostate	625 NX

Basal keratinocytes	171 NX
Skin	171 NX

Bipolar cells	2 NX
Eye	2 NX

Cardiomyocytes	76 NX
Heart muscle	76 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	13 NX
Lung	13 NX

Club cells	40 NX
Lung	40 NX

Collecting duct cells	4 NX
Kidney	4 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	113 NX
Placenta	112 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	103 NX
Pancreas	103 NX

Early spermatids	1 NX
Testis	0 NX

Endothelial cells	82 NX
Skin	174 NX
Pancreas	165 NX
Prostate	150 NX
Eye	122 NX
Placenta	121 NX
Lung	82 NX
Liver	54 NX
Heart muscle	37 NX
Testis	19 NX

Enterocytes	88 NX
Colon	251 NX
Rectum	196 NX
Small intestine	13 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	27 NX
Pancreas	27 NX

Extravillous trophoblasts	469 NX
Placenta	469 NX

Fibroblasts	91 NX
Prostate	504 NX
Skin	112 NX
Placenta	88 NX
Heart muscle	80 NX
Lung	52 NX

Glandular cells	190 NX
Prostate	190 NX

Granulocytes	9 NX
Colon	9 NX
Lung	9 NX

Hepatocytes	14 NX
Liver	14 NX

Hofbauer cells	64 NX
Placenta	64 NX

Horizontal cells	3 NX
Eye	3 NX

Intestinal endocrine cells	65 NX
Colon	78 NX
Rectum	52 NX

Ito cells	118 NX
Liver	118 NX

Kupffer cells	66 NX
Liver	66 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	123 NX
Testis	123 NX

Macrophages	65 NX
Prostate	244 NX
Pancreas	232 NX
Lung	116 NX
Kidney	62 NX
Skin	59 NX
Testis	7 NX

Melanocytes	39 NX
Skin	39 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	8 NX
Pancreas	8 NX

Mucus-secreting cells	96 NX
Colon	160 NX
Small intestine	158 NX
Rectum	32 NX

Muller glia cells	4 NX
Eye	4 NX

Pancreatic endocrine cells	57 NX
Pancreas	57 NX

Paneth cells	32 NX
Colon	726 NX
Rectum	32 NX
Small intestine	28 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	51 NX
Kidney	51 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	71 NX
Prostate	123 NX
Skin	85 NX
Pancreas	71 NX
Heart muscle	26 NX

Spermatocytes	5 NX
Testis	5 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	110 NX
Skin	110 NX

Syncytiotrophoblasts	907 NX
Placenta	907 NX

T-cells	7 NX
Prostate	92 NX
Skin	23 NX
Lung	14 NX
Colon	9 NX
Liver	6 NX
Kidney	5 NX

Undifferentiated cells	25 NX
Colon	79 NX
Rectum	27 NX
Small intestine	16 NX

Urothelial cells	220 NX
Prostate	220 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.