Cell type atlas - ADD3 - The Human Protein Atlas

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ADD3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADD3
Gene descriptionⁱ Full gene name according to HGNC.	Adducin 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Muller glia cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff, ASC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Muller glia cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	42 NX
Lung	42 NX

B-cells	59 NX
Kidney	94 NX
Liver	54 NX
Colon	48 NX

Basal glandular cells	30 NX
Prostate	30 NX

Basal keratinocytes	50 NX
Skin	50 NX

Bipolar cells	24 NX
Eye	24 NX

Cardiomyocytes	115 NX
Heart muscle	115 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	115 NX
Lung	115 NX

Club cells	53 NX
Lung	53 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	57 NX
Eye	57 NX

Cytotrophoblasts	51 NX
Placenta	51 NX

Distal tubular cells	51 NX
Kidney	51 NX

Ductal cells	19 NX
Pancreas	19 NX

Early spermatids	39 NX
Testis	39 NX

Endothelial cells	47 NX
Lung	222 NX
Skin	138 NX
Heart muscle	120 NX
Liver	117 NX
Pancreas	47 NX
Placenta	42 NX
Testis	36 NX
Prostate	25 NX
Eye	19 NX

Enterocytes	93 NX
Rectum	163 NX
Small intestine	129 NX
Colon	67 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	54 NX
Pancreas	54 NX

Extravillous trophoblasts	11 NX
Placenta	11 NX

Fibroblasts	103 NX
Heart muscle	257 NX
Skin	173 NX
Prostate	102 NX
Placenta	75 NX
Lung	60 NX

Glandular cells	48 NX
Prostate	48 NX

Granulocytes	25 NX
Colon	28 NX
Lung	23 NX

Hepatocytes	10 NX
Liver	10 NX

Hofbauer cells	22 NX
Placenta	22 NX

Horizontal cells	110 NX
Eye	110 NX

Intestinal endocrine cells	98 NX
Colon	105 NX
Rectum	91 NX

Ito cells	123 NX
Liver	123 NX

Kupffer cells	98 NX
Liver	98 NX

Late spermatids	16 NX
Testis	16 NX

Leydig cells	210 NX
Testis	210 NX

Macrophages	39 NX
Kidney	56 NX
Testis	51 NX
Lung	48 NX
Prostate	39 NX
Skin	28 NX
Pancreas	9 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	53 NX
Small intestine	80 NX
Rectum	61 NX
Colon	19 NX

Muller glia cells	293 NX
Eye	293 NX

Pancreatic endocrine cells	52 NX
Pancreas	52 NX

Paneth cells	162 NX
Small intestine	277 NX
Rectum	162 NX
Colon	23 NX

Peritubular cells	236 NX
Testis	236 NX

Proximal tubular cells	121 NX
Kidney	121 NX

Rod photoreceptor cells	117 NX
Eye	117 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	21 NX
Heart muscle	52 NX
Skin	21 NX
Pancreas	18 NX
Prostate	14 NX

Spermatocytes	104 NX
Testis	104 NX

Spermatogonia	52 NX
Testis	52 NX

Suprabasal keratinocytes	44 NX
Skin	44 NX

Syncytiotrophoblasts	19 NX
Placenta	19 NX

T-cells	67 NX
Lung	161 NX
Kidney	120 NX
Liver	74 NX
Skin	59 NX
Colon	36 NX
Prostate	18 NX

Undifferentiated cells	150 NX
Small intestine	205 NX
Rectum	150 NX
Colon	40 NX

Urothelial cells	82 NX
Prostate	82 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.