Cell type atlas - GLUD1 - The Human Protein Atlas

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GLUD1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GLUD1
Gene descriptionⁱ Full gene name according to HGNC.	Glutamate dehydrogenase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Hep G2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	19 NX
Lung	19 NX

B-cells	40 NX
Kidney	76 NX
Colon	54 NX
Liver	21 NX

Basal glandular cells	53 NX
Prostate	53 NX

Basal keratinocytes	94 NX
Skin	94 NX

Bipolar cells	21 NX
Eye	21 NX

Cardiomyocytes	50 NX
Heart muscle	50 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	46 NX
Lung	46 NX

Collecting duct cells	58 NX
Kidney	58 NX

Cone photoreceptor cells	35 NX
Eye	35 NX

Cytotrophoblasts	77 NX
Placenta	77 NX

Distal tubular cells	133 NX
Kidney	133 NX

Ductal cells	28 NX
Pancreas	28 NX

Early spermatids	11 NX
Testis	11 NX

Endothelial cells	46 NX
Skin	91 NX
Liver	61 NX
Eye	51 NX
Prostate	46 NX
Pancreas	43 NX
Heart muscle	40 NX
Testis	36 NX
Placenta	34 NX
Lung	29 NX

Enterocytes	55 NX
Small intestine	120 NX
Rectum	63 NX
Colon	37 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	29 NX
Pancreas	29 NX

Extravillous trophoblasts	52 NX
Placenta	52 NX

Fibroblasts	55 NX
Skin	156 NX
Prostate	80 NX
Heart muscle	55 NX
Placenta	44 NX
Lung	20 NX

Glandular cells	96 NX
Prostate	96 NX

Granulocytes	44 NX
Colon	74 NX
Lung	14 NX

Hepatocytes	357 NX
Liver	357 NX

Hofbauer cells	63 NX
Placenta	63 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	38 NX
Colon	48 NX
Rectum	28 NX

Ito cells	50 NX
Liver	50 NX

Kupffer cells	67 NX
Liver	67 NX

Late spermatids	19 NX
Testis	19 NX

Leydig cells	81 NX
Testis	81 NX

Macrophages	68 NX
Skin	165 NX
Prostate	77 NX
Testis	69 NX
Kidney	67 NX
Lung	45 NX
Pancreas	23 NX

Melanocytes	100 NX
Skin	100 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	31 NX
Pancreas	31 NX

Mucus-secreting cells	45 NX
Small intestine	59 NX
Rectum	45 NX
Colon	32 NX

Muller glia cells	133 NX
Eye	133 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	42 NX
Rectum	42 NX
Small intestine	42 NX
Colon	20 NX

Peritubular cells	85 NX
Testis	85 NX

Proximal tubular cells	120 NX
Kidney	120 NX

Rod photoreceptor cells	60 NX
Eye	60 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	76 NX
Skin	88 NX
Prostate	76 NX
Pancreas	53 NX
Heart muscle	32 NX

Spermatocytes	10 NX
Testis	10 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	107 NX
Skin	107 NX

Syncytiotrophoblasts	40 NX
Placenta	40 NX

T-cells	55 NX
Skin	289 NX
Colon	63 NX
Prostate	61 NX
Kidney	53 NX
Liver	51 NX
Lung	19 NX

Undifferentiated cells	41 NX
Small intestine	49 NX
Rectum	41 NX
Colon	33 NX

Urothelial cells	76 NX
Prostate	76 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.