Cell type atlas - COMMD3 - The Human Protein Atlas

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COMMD3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COMMD3
Gene descriptionⁱ Full gene name according to HGNC.	COMM domain containing 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HDLM-2, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	57 NX
Liver	75 NX
Kidney	71 NX
Colon	27 NX

Basal glandular cells	44 NX
Prostate	44 NX

Basal keratinocytes	34 NX
Skin	34 NX

Bipolar cells	40 NX
Eye	40 NX

Cardiomyocytes	90 NX
Heart muscle	90 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	36 NX
Lung	36 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	50 NX
Placenta	50 NX

Distal tubular cells	100 NX
Kidney	100 NX

Ductal cells	71 NX
Pancreas	71 NX

Early spermatids	325 NX
Testis	325 NX

Endothelial cells	37 NX
Placenta	68 NX
Pancreas	57 NX
Heart muscle	49 NX
Liver	47 NX
Testis	37 NX
Eye	29 NX
Skin	28 NX
Lung	18 NX
Prostate	17 NX

Enterocytes	27 NX
Small intestine	59 NX
Rectum	23 NX
Colon	10 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	72 NX
Pancreas	72 NX

Extravillous trophoblasts	44 NX
Placenta	44 NX

Fibroblasts	44 NX
Heart muscle	75 NX
Placenta	44 NX
Skin	43 NX
Lung	26 NX
Prostate	20 NX

Glandular cells	25 NX
Prostate	25 NX

Granulocytes	53 NX
Colon	55 NX
Lung	51 NX

Hepatocytes	54 NX
Liver	54 NX

Hofbauer cells	87 NX
Placenta	87 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	40 NX
Colon	44 NX
Rectum	35 NX

Ito cells	33 NX
Liver	33 NX

Kupffer cells	49 NX
Liver	49 NX

Late spermatids	68 NX
Testis	68 NX

Leydig cells	54 NX
Testis	54 NX

Macrophages	53 NX
Kidney	75 NX
Pancreas	63 NX
Skin	61 NX
Testis	58 NX
Prostate	48 NX
Lung	38 NX

Melanocytes	51 NX
Skin	51 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	107 NX
Pancreas	107 NX

Mucus-secreting cells	39 NX
Small intestine	42 NX
Colon	38 NX
Rectum	36 NX

Muller glia cells	65 NX
Eye	65 NX

Pancreatic endocrine cells	63 NX
Pancreas	63 NX

Paneth cells	35 NX
Rectum	45 NX
Small intestine	35 NX
Colon	20 NX

Peritubular cells	53 NX
Testis	53 NX

Proximal tubular cells	83 NX
Kidney	83 NX

Rod photoreceptor cells	63 NX
Eye	63 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	48 NX
Pancreas	75 NX
Heart muscle	51 NX
Skin	46 NX
Prostate	26 NX

Spermatocytes	23 NX
Testis	23 NX

Spermatogonia	29 NX
Testis	29 NX

Suprabasal keratinocytes	45 NX
Skin	45 NX

Syncytiotrophoblasts	22 NX
Placenta	22 NX

T-cells	42 NX
Kidney	69 NX
Prostate	48 NX
Liver	42 NX
Skin	33 NX
Lung	32 NX
Colon	32 NX

Undifferentiated cells	36 NX
Small intestine	54 NX
Rectum	32 NX
Colon	23 NX

Urothelial cells	34 NX
Prostate	34 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.