Cell type atlas - UGCG - The Human Protein Atlas

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UGCG

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UGCG
Gene descriptionⁱ Full gene name according to HGNC.	UDP-glucose ceramide glucosyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (LHCN-M2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	49 NX
Lung	48 NX

B-cells	30 NX
Kidney	62 NX
Colon	33 NX
Liver	21 NX

Basal glandular cells	124 NX
Prostate	124 NX

Basal keratinocytes	67 NX
Skin	67 NX

Bipolar cells	26 NX
Eye	26 NX

Cardiomyocytes	9 NX
Heart muscle	9 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	115 NX
Lung	115 NX

Club cells	114 NX
Lung	114 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	59 NX
Eye	59 NX

Cytotrophoblasts	6 NX
Placenta	6 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	98 NX
Pancreas	98 NX

Early spermatids	15 NX
Testis	14 NX

Endothelial cells	73 NX
Prostate	162 NX
Skin	158 NX
Placenta	117 NX
Lung	96 NX
Liver	76 NX
Heart muscle	58 NX
Eye	26 NX
Testis	15 NX
Pancreas	11 NX

Enterocytes	53 NX
Colon	100 NX
Small intestine	37 NX
Rectum	33 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	44 NX
Pancreas	44 NX

Extravillous trophoblasts	10 NX
Placenta	10 NX

Fibroblasts	46 NX
Prostate	176 NX
Skin	65 NX
Lung	65 NX
Heart muscle	20 NX
Placenta	14 NX

Glandular cells	157 NX
Prostate	157 NX

Granulocytes	10 NX
Lung	12 NX
Colon	9 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	20 NX
Placenta	20 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	18 NX
Colon	24 NX
Rectum	12 NX

Ito cells	93 NX
Liver	93 NX

Kupffer cells	30 NX
Liver	30 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	46 NX
Testis	46 NX

Macrophages	31 NX
Prostate	129 NX
Skin	69 NX
Testis	30 NX
Pancreas	28 NX
Lung	27 NX
Kidney	23 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	70 NX
Pancreas	70 NX

Mucus-secreting cells	42 NX
Colon	81 NX
Small intestine	43 NX
Rectum	20 NX

Muller glia cells	8 NX
Eye	8 NX

Pancreatic endocrine cells	67 NX
Pancreas	67 NX

Paneth cells	21 NX
Colon	133 NX
Small intestine	21 NX
Rectum	19 NX

Peritubular cells	36 NX
Testis	36 NX

Proximal tubular cells	56 NX
Kidney	56 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	61 NX
Prostate	147 NX
Skin	94 NX
Pancreas	23 NX
Heart muscle	15 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	107 NX
Skin	107 NX

Syncytiotrophoblasts	3 NX
Placenta	3 NX

T-cells	27 NX
Lung	60 NX
Prostate	52 NX
Kidney	35 NX
Skin	35 NX
Liver	16 NX
Colon	13 NX

Undifferentiated cells	13 NX
Colon	32 NX
Small intestine	13 NX
Rectum	12 NX

Urothelial cells	447 NX
Prostate	447 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.